eMERGE Phase IV Clinical Center at Mass General Brigham
About This Grant
PROJECT SUMMARY The electronic MEdical Records and GEnomics (eMERGE IV) Network is a national network organized and funded by the National Human Genome Research Institute (NHGRI) that combines DNA biorepositories with electronic health record (EHR) systems for large scale, high- throughput genetic research in support of implementing genomic medicine. In 2020, eMERGE IV launched a study of genomic risk assessment and return of genomically informed risk assessments (GIRA) with healthcare recommendations for 11 common diseases to a cohort of 23,840 participants (including 4,255 children) from primary care practices across 10 institutions. The primary outcome is analysis of uptake of pre-specified care recommendations (provider action, participant action) across all conditions at 12-months post-GIRA return in high- risk vs. not high-risk participants as defined by the Network-designed statistical analysis plan. Mass General Brigham (MGB) has been an active and engaged eMERGE IV site with specific expertise in EHR data extraction, quality control (QC) processes, and use of large language models (LLMs) to define EHR outcomes. We enrolled and completed GIRA return for 2502 MGB participants, uploaded the results to the EHR, surveyed providers, implemented post- RoR participant surveys, and extracted and QC’d the 6-month EHR outcomes. Extraction of 12- month EHR outcomes is underway and expected to finish in April 2026. Our site has provided Network leadership and was deeply engaged with the other sites and Network leadership throughout the study. In this proposal we request a one-year extension of funding for a “Year 7” from 05/01/2026 to 4/30/2027. This extension will allow the MGB eMERGE IV site to QC and harmonize 12-month outcome data, analyze whether returning high risk GIRA leads to new preventive and screening healthcare actions, and disseminate results through manuscripts to inform implementation of genomic medicine in healthcare for adults and children. We intend to work with the NHGRI leadership and Network sites to continue to discover and publish the learnings from the eMERGE IV genomic risk implementation study following the plans for an extension year that we collaboratively designed as a network.
Grant Summary
eMERGE Phase IV Clinical Center at Mass General Brigham is a NHGRI - National Human Genome Research Institute grant providing up to $770K for university, nonprofit, healthcare org. Applications are due 2027-04-30 (open). Check eligibility and apply with FindGrants.
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Focus Areas
Eligibility
How to Apply
Up to $770K
2027-04-30
- 1Confirm your organization is eligible for eMERGE Phase IV Clinical Center at Mass General Brigham from NHGRI - National Human Genome Research Institute, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NHGRI - National Human Genome Research Institute before the deadline.
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eMERGE Phase IV Clinical Center at Mass General Brigham: Frequently Asked Questions
Who is eligible for the eMERGE Phase IV Clinical Center at Mass General Brigham?
eMERGE Phase IV Clinical Center at Mass General Brigham is offered by NHGRI - National Human Genome Research Institute and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the eMERGE Phase IV Clinical Center at Mass General Brigham provide?
eMERGE Phase IV Clinical Center at Mass General Brigham provides up to $770K per award from NHGRI - National Human Genome Research Institute. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the eMERGE Phase IV Clinical Center at Mass General Brigham deadline?
Applications for eMERGE Phase IV Clinical Center at Mass General Brigham are due 2027-04-30 (open). Because deadlines can change, verify the date with the funder, NHGRI - National Human Genome Research Institute, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the eMERGE Phase IV Clinical Center at Mass General Brigham?
To apply for eMERGE Phase IV Clinical Center at Mass General Brigham, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NHGRI - National Human Genome Research Institute.