Converting wound scar into healing with regeneration
NIAMS - National Institute of Arthritis and Musculoskeletal and Skin Diseases
About This Grant
Summary The goal of this grant is to understand the regulation of SHH-driven hair follicle neogenesis (HFN) in adult wounds. While much research focuses on wound healing, scarring, particularly from burns, trauma, and surgeries, remains largely overlooked. Scarring affects over 50% of the U.S. population, with 50 to 80 million new scars formed annually, resulting in significant cosmetic, psychological, and social burdens. Yet, no effective anti-scarring therapy currently exists. We previously developed a model in which large wounds in mice can lead to efficient hair follicle regeneration, opening the door to understanding the molecular mechanisms of HFN. Our lab has identified Sonic Hedgehog (SHH) as a critical factor in determining whether wounds heal with hair follicle regeneration or fibrosis and how SHH interacts with WNT and BMP signaling pathways for successful HFN. These findings raise new possibilities about the roles of SHH in the unresolved issue of wound scar remodeling: Can SHH remodel existing scars? If so, how long after wounding is it effective? And can this approach be applied to human scars? Furthermore, a longstanding question is how a developmental signal like SHH can be induced after wounding and what prerequisites are necessary for this signal to occur. This project aims to investigate the effect of SHH on old scars long after healing (Aim1), explore one of the upstream mechanisms we’ve identified as essential for SHH induction in large wounds (e.g., angiogenesis) (Aim 2), and examine how SHH signaling can similarly induce HFN using human fibroblasts (Aim 3).
Grant Summary
Converting wound scar into healing with regeneration is a NIAMS - National Institute of Arthritis and Musculoskeletal and Skin Diseases grant providing up to $595K for university, nonprofit, healthcare org. Applications are due 2031-02-28 (open). Check eligibility and apply with FindGrants.
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Focus Areas
Eligibility
How to Apply
Up to $595K
2031-02-28
- 1Confirm your organization is eligible for Converting wound scar into healing with regeneration from NIAMS - National Institute of Arthritis and Musculoskeletal and Skin Diseases, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIAMS - National Institute of Arthritis and Musculoskeletal and Skin Diseases before the deadline.
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Converting wound scar into healing with regeneration: Frequently Asked Questions
Who is eligible for the Converting wound scar into healing with regeneration?
Converting wound scar into healing with regeneration is offered by NIAMS - National Institute of Arthritis and Musculoskeletal and Skin Diseases and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Converting wound scar into healing with regeneration provide?
Converting wound scar into healing with regeneration provides up to $595K per award from NIAMS - National Institute of Arthritis and Musculoskeletal and Skin Diseases. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Converting wound scar into healing with regeneration deadline?
Applications for Converting wound scar into healing with regeneration are due 2031-02-28 (open). Because deadlines can change, verify the date with the funder, NIAMS - National Institute of Arthritis and Musculoskeletal and Skin Diseases, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Converting wound scar into healing with regeneration?
To apply for Converting wound scar into healing with regeneration, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIAMS - National Institute of Arthritis and Musculoskeletal and Skin Diseases.