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View full policyCentral Apnea in Heart Failure: Physiological Mechanisms to Inform Treatment
About This Grant
Our objective is to test mechanistic pathways to inform future clinical studies investigating the potential treatment of central sleep apnea (CSA) in veterans with heart failure and reduced ejection fraction (HF). The long-term goal is to transform the care of veterans living with these two conditions. We will test two key determinants of recurrent CSA in veterans with HF: augmented peripheral chemoreceptor activity and respiratory arousals. Specifically, the project will utilize a novel PAP plus approach, combining PAP therapy to alleviate upper airway obstruction with a specific intervention to target the mechanistic underpinnings of CSA. Our experiments will capitalize on the plasticity of the CO2 reserve as the gateway to the resolution of CSA. We will suppress arousals or dampen augmented PCR activity while maintaining upper airway patency with PAP. The long-term goal is to inform future multi-modality intervention studies. To this end, the following Specific Aims will be addressed in veterans with HF and CSA. Specific Aim 1: To determine the effect of decreasing respiratory arousals on the propensity to CSA. Hypothesis 1: Four weeks of combined PAP and trazodone therapy will be superior to PAP alone in elevating the arousal threshold, widening the CO2 reserve (primary outcome), and decreasing CSA indices. Specific Aim 2: To determine the effect of decreased peripheral chemoreceptor sensitivity on the propensity to CSA. Hypothesis 2: Four weeks of combined PAP and supplemental O2 (targeting peripheral chemoreceptor sensitivity) will be superior to PAP alone in widening the CO2 reserve (primary outcome), reducing controller gain, and decreasing CSA indices. The proposed studies are innovative, testing mechanistic “PAP Plus” approach targeting underlying causes of CSA and alleviating upper airway obstruction with PAP. These studies will inform future clinical trials to transform central apnea care in patients with heart failure.
Grant Summary
Central Apnea in Heart Failure: Physiological Mechanisms to Inform Treatment is a NIH grant providing funding that varies by award for university, nonprofit, healthcare org. Applications are due 2030-03-31 (open). Check eligibility and apply with FindGrants.
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Eligibility
How to Apply
Up to $0K
2030-03-31
- 1Confirm your organization is eligible for Central Apnea in Heart Failure: Physiological Mechanisms to Inform Treatment from NIH, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIH before the deadline.
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Central Apnea in Heart Failure: Physiological Mechanisms to Inform Treatment: Frequently Asked Questions
Who is eligible for the Central Apnea in Heart Failure: Physiological Mechanisms to Inform Treatment?
Central Apnea in Heart Failure: Physiological Mechanisms to Inform Treatment is offered by NIH and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Central Apnea in Heart Failure: Physiological Mechanisms to Inform Treatment provide?
Central Apnea in Heart Failure: Physiological Mechanisms to Inform Treatment provides an amount that varies by award per award from NIH. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Central Apnea in Heart Failure: Physiological Mechanisms to Inform Treatment deadline?
Applications for Central Apnea in Heart Failure: Physiological Mechanisms to Inform Treatment are due 2030-03-31 (open). Because deadlines can change, verify the date with the funder, NIH, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Central Apnea in Heart Failure: Physiological Mechanisms to Inform Treatment?
To apply for Central Apnea in Heart Failure: Physiological Mechanisms to Inform Treatment, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIH.