A Randomized Clinical Trial of a Peer Education Intervention to Promote Social Diffusion of Overdose Prevention and Drug Use Cessation in High Burden Communities
About This Grant
Abstract: The US opioid epidemic has significantly impacted public health, with high levels of opiate dependence and a surge in overdoses. The increasing prevalence of fentanyl and xylazine in the drug supply underscores the importance of novel approaches. Additionally, times of withdrawal have been found to increase overdose risk behaviors, highlighting a need to target this period. Particularly in the context of xylazine, as naloxone does not reverse the effect of xylazine-induced respiratory depression, enrollment and retention in medications for opioid use disorder (MOUD) is vital to reduce drug overdoses. In our prior work, we have shown that PWUO can be trained as peer educators (PEs) for overdose prevention, but we have not integrated withdrawal management or a social network approach to MOUD engagement. This five year proposal seeks to develop, implement, and rigorously evaluate a novel PE intervention designed to prevent overdoses and promote MOUD and drug use cessation among a population of PWUO disproportionally impacted by overdose (Funding Option B). The intervention has three novel components: (a) social network diffusion of overdose prevention and MOUD promotion, (b) strategies to address high-risk withdrawal periods, and (c) Certified Peer Recovery Specialist (CPRS)/ Contingency Management (CM) for MOUD engagement. Using an RCT study design, 300 index PWUO will be recruited along with 300 of their network members who use opioids. The indexes will be randomly assigned to the (1) standard of care (SOC) or (2) an experimental peer education condition (PEC). The proposed design allows for the examination of the effectiveness of the intervention on indexes and diffusion of behavior change to network members. The RE-AIM framework will guide the collection of qualitative interview data to identify barriers and facilitators to intervention implementation. Assessments will occur every 3 months for one year. 1. Development and Pilot Testing: Design and pilot test intervention components that diffuse overdose prevention behaviors and MOUD within social networks, promote overdose prevention during withdrawal, and enhance MOUD engagement through CPRS/CM. 2. Implementation of RCT: Evaluate the intervention in a 1:1 RCT, testing an intervention that includes (a) social network diffusion of overdose prevention and MOUD promotion, (b) strategies to address high-risk withdrawal periods, and (c) CPRS/CM for MOUD engagement (N=600; 300 index participants, 300 network members). 3. Evaluation of Outcomes: Assess changes in nonfatal overdose, drug use cessation, MOUD engagement, and overdose prevention behaviors among index participants, as well as the diffusion of these behaviors to their social network members.
Grant Summary
A Randomized Clinical Trial of a Peer Education Intervention to Promote Social Diffusion of Overdose Prevention and Drug Use Cessation in High Burden Communities is a NCIPC - National Center for Injury Prevention and Control grant providing up to $700K for university, nonprofit, healthcare org. Applications are due 2030-09-29 (open). Check eligibility and apply with FindGrants.
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Focus Areas
Eligibility
How to Apply
Up to $700K
2030-09-29
- 1Confirm your organization is eligible for A Randomized Clinical Trial of a Peer Education Intervention to Promote Social Diffusion of Overdose Prevention and Drug Use Cessation in High Burden Communities from NCIPC - National Center for Injury Prevention and Control, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NCIPC - National Center for Injury Prevention and Control before the deadline.
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A Randomized Clinical Trial of a Peer Education Intervention to Promote Social Diffusion of Overdose Prevention and Drug Use Cessation in High Burden Communities: Frequently Asked Questions
Who is eligible for the A Randomized Clinical Trial of a Peer Education Intervention to Promote Social Diffusion of Overdose Prevention and Drug Use Cessation in High Burden Communities?
A Randomized Clinical Trial of a Peer Education Intervention to Promote Social Diffusion of Overdose Prevention and Drug Use Cessation in High Burden Communities is offered by NCIPC - National Center for Injury Prevention and Control and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the A Randomized Clinical Trial of a Peer Education Intervention to Promote Social Diffusion of Overdose Prevention and Drug Use Cessation in High Burden Communities provide?
A Randomized Clinical Trial of a Peer Education Intervention to Promote Social Diffusion of Overdose Prevention and Drug Use Cessation in High Burden Communities provides up to $700K per award from NCIPC - National Center for Injury Prevention and Control. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the A Randomized Clinical Trial of a Peer Education Intervention to Promote Social Diffusion of Overdose Prevention and Drug Use Cessation in High Burden Communities deadline?
Applications for A Randomized Clinical Trial of a Peer Education Intervention to Promote Social Diffusion of Overdose Prevention and Drug Use Cessation in High Burden Communities are due 2030-09-29 (open). Because deadlines can change, verify the date with the funder, NCIPC - National Center for Injury Prevention and Control, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the A Randomized Clinical Trial of a Peer Education Intervention to Promote Social Diffusion of Overdose Prevention and Drug Use Cessation in High Burden Communities?
To apply for A Randomized Clinical Trial of a Peer Education Intervention to Promote Social Diffusion of Overdose Prevention and Drug Use Cessation in High Burden Communities, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NCIPC - National Center for Injury Prevention and Control.