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View full policyDevelopment of 3D Multi-cellular Cardiac Tissues for Modeling Delayed Radiation-induced Injury
About This Grant
Project Summary Accidental exposure to ionizing radiation (IR) poses a significant risk for cardiovascular morbidity, a leading cause of mortality among irradiated populations. However, the mechanisms driving long-term cardiovascular risks remain poorly understood. IR disrupts immune homeostasis, exacerbating chronic inflammation and accelerating pathological remodeling. The current multi-PI U01 proposal seeks to address this knowledge gap by developing an innovative extracorporeal system composed of human stem cell derivatives to identify biomarkers and medical countermeasures (MCMs) for radiation-induced delayed cardiac remodeling (RidCR). In Milestone 1, we will establish a 3D cardiac-immune co-culture system using iPSC-derived cardiomyocytes, endothelial cells, fibroblasts, and macrophages to simulate the immune-competent 3D microenvironment. Optimized culture conditions will be validated in 3D engineered cardiac tissues (EHTs) for physiological and inflammatory responses. In Milestone 2, we will perform multi-omics analyses on irradiated EHTs and parallel animal models to identify molecular signatures of RidCR via multi-omics and functional assessments of tissue contractility. In Milestone 3, AI/ML will integrate the generated datasets to predict candidate MCMs, which will be validated in vitro and tested in vivo using a protracted irradiation mouse model. Comprehensive evaluations will assess the efficacy of the lead MCM in mitigating RidCR.
Grant Summary
Development of 3D Multi-cellular Cardiac Tissues for Modeling Delayed Radiation-induced Injury is a OD - NIH Office of the Director grant providing up to $539K for university, nonprofit, healthcare org. Applications are due 2031-03-31 (open). Check eligibility and apply with FindGrants.
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Focus Areas
Eligibility
How to Apply
Up to $539K
2031-03-31
- 1Confirm your organization is eligible for Development of 3D Multi-cellular Cardiac Tissues for Modeling Delayed Radiation-induced Injury from OD - NIH Office of the Director, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to OD - NIH Office of the Director before the deadline.
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Development of 3D Multi-cellular Cardiac Tissues for Modeling Delayed Radiation-induced Injury: Frequently Asked Questions
Who is eligible for the Development of 3D Multi-cellular Cardiac Tissues for Modeling Delayed Radiation-induced Injury?
Development of 3D Multi-cellular Cardiac Tissues for Modeling Delayed Radiation-induced Injury is offered by OD - NIH Office of the Director and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Development of 3D Multi-cellular Cardiac Tissues for Modeling Delayed Radiation-induced Injury provide?
Development of 3D Multi-cellular Cardiac Tissues for Modeling Delayed Radiation-induced Injury provides up to $539K per award from OD - NIH Office of the Director. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Development of 3D Multi-cellular Cardiac Tissues for Modeling Delayed Radiation-induced Injury deadline?
Applications for Development of 3D Multi-cellular Cardiac Tissues for Modeling Delayed Radiation-induced Injury are due 2031-03-31 (open). Because deadlines can change, verify the date with the funder, OD - NIH Office of the Director, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Development of 3D Multi-cellular Cardiac Tissues for Modeling Delayed Radiation-induced Injury?
To apply for Development of 3D Multi-cellular Cardiac Tissues for Modeling Delayed Radiation-induced Injury, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from OD - NIH Office of the Director.