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View full policy700 MHz NMR console and probe upgrade for biomolecular and 19 F NMR studies at theUniversity of Minnesota
About This Grant
This Shared Instrumentation Grant application requests funds to upgrade the 700 MHz NMR spectrometer at the Minnesota NMR Center (MNMR), a University of Minnesota core facility that serves as a hub for high-field NMR spectroscopy. The existing instrument is currently equipped with a 22-year-old Bruker Avance I console and TXI cryoprobe that are now obsolete, increasingly unreliable, and no longer capable of supporting many state-of-the- art experimental experiments. Hardware failures, including cryoplatform instability, auto-tuning issues, and console communication problems, have significantly reduced instrument availability and limited its utility, even as user demand continues to grow. The manufacturer no longer guarantees part availability or technical support for this aging platform, posing an ongoing risk to research continuity. The proposed upgrade includes a Bruker Avance NEO console and QCI-F CryoProbe. This combination will restore the instrument to full operational capacity and provide a significant technical leap in sensitivity, stability, and experimental flexibility. Specifically, the upgraded system will deliver improvements in 13C sensitivity, enable simultaneous 1H decoupling during 19F detection, and support 19F-detected experiments. These capabilities will open new experimental avenues for investigators studying conformational exchange, ligand screening, protein- small molecule interactions, intrinsically disordered proteins, and macromolecular dynamics on the µs–ms timescale. In addition, the system will support automation features, as well as compatibility with TopSpin 4.x software and the existing autosampler, further improving efficiency, reproducibility, and throughput. MNMR currently supports 32-36 active research groups each year, whose work results in 30-40 peer-reviewed publications annually and is supported by 16-20 NIH-funded projects. The user base spans five colleges and includes researchers from more than a dozen departments across the Twin Cities campus. Current users apply NMR to a broad spectrum of biomedical problems, including DNA repair, cancer signaling, infectious disease, metabolism, and drug discovery. The MNMR Center is also an important training resource, providing hands-on experience in high-field NMR methods for graduate students, postdoctoral fellows, and technical staff. The requested upgrade will alleviate the significant pressure currently placed on the Center’s two 600 MHz instruments, which are nearing full capacity due to users shifting away from the outdated 700 MHz instrument. By restoring this underutilized instrument to full functionality and enabling advanced biomolecular and small molecule NMR experiments, the upgrade will enhance access, expand capacity, and improve data quality for a broad and growing community of NIH-funded investigators. This investment will not only strengthen ongoing research programs but also attract new users to the MNMR Center. Thus, this proposal addresses an urgent instrumentation need and will have immediate and lasting impact on NIH-supported research across structural biology, chemical biology, and biomedical sciences at the University of Minnesota.
Grant Summary
700 MHz NMR console and probe upgrade for biomolecular and 19 F NMR studies at theUniversity of Minnesota is a OD - NIH Office of the Director grant providing up to $1.3M for university, nonprofit, healthcare org. Applications are due 2027-07-14 (open). Check eligibility and apply with FindGrants.
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Focus Areas
Eligibility
How to Apply
Up to $1.3M
2027-07-14
- 1Confirm your organization is eligible for 700 MHz NMR console and probe upgrade for biomolecular and 19 F NMR studies at theUniversity of Minnesota from OD - NIH Office of the Director, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to OD - NIH Office of the Director before the deadline.
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700 MHz NMR console and probe upgrade for biomolecular and 19 F NMR studies at theUniversity of Minnesota: Frequently Asked Questions
Who is eligible for the 700 MHz NMR console and probe upgrade for biomolecular and 19 F NMR studies at theUniversity of Minnesota?
700 MHz NMR console and probe upgrade for biomolecular and 19 F NMR studies at theUniversity of Minnesota is offered by OD - NIH Office of the Director and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the 700 MHz NMR console and probe upgrade for biomolecular and 19 F NMR studies at theUniversity of Minnesota provide?
700 MHz NMR console and probe upgrade for biomolecular and 19 F NMR studies at theUniversity of Minnesota provides up to $1.3M per award from OD - NIH Office of the Director. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the 700 MHz NMR console and probe upgrade for biomolecular and 19 F NMR studies at theUniversity of Minnesota deadline?
Applications for 700 MHz NMR console and probe upgrade for biomolecular and 19 F NMR studies at theUniversity of Minnesota are due 2027-07-14 (open). Because deadlines can change, verify the date with the funder, OD - NIH Office of the Director, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the 700 MHz NMR console and probe upgrade for biomolecular and 19 F NMR studies at theUniversity of Minnesota?
To apply for 700 MHz NMR console and probe upgrade for biomolecular and 19 F NMR studies at theUniversity of Minnesota, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from OD - NIH Office of the Director.