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View full policyCell Avidity Measurement with the Lumicks Avidion to Evaluate the Effector T cell Function against Cancer
About This Grant
Project Summary/Abstract: We request funding through the NIH S10 Shared Instrumentation Grant program to acquire a LUMICKS Avidion Cell Avidity Analyzer, a transformative high-throughput platform designed to quantitatively measure cell-cell interaction avidity. Currently, our institution faces significant limitations in systematically assessing cellular avidity, a critical parameter predictive of efficacy in adoptive cellular immunotherapies such as chimeric antigen receptor (CAR) T-cell therapies. The proposed instrument addresses this gap, enabling simultaneous, high-throughput quantification of avidity across hundreds of experimental conditions, overcoming bottlenecks of existing low- throughput methods. The Avidion analyzer uniquely integrates advanced centrifugal force-based technology, multicolor fluorescence imaging, automated liquid handling, and robotic cartridge management. This combination provides unprecedented sensitivity, throughput, and specificity in measuring interactions between engineered immune cells and their targets. Our major and minor users propose projects leveraging this advanced capability to significantly accelerate discovery and clinical translation. Major user projects include: (1) Systematic CRISPR-based screening of adhesion and costimulatory molecules influencing immune synapse formation and CAR T functionality; (2) High-throughput quantification of anti-CD79 CAR T-cell avidity to predict in vivo efficacy in lymphoma models; (3) Development of peptide-centric CAR-T cells targeting KRAS G12V and other neoantigens in solid tumors; (4) Identification of resistance mechanisms in BCMA- targeted immunotherapies in multiple myeloma through avidity profiling; and (5) Characterization of T- cell avidity impairments caused by lipid-rich tumor microenvironments in ovarian cancer ascites. Minor users will utilize the instrument to optimize novel CAR constructs, synthetic adhesion molecules, and T- cell receptor-based therapies, addressing critical scientific and clinical questions across hematologic malignancies and solid tumors. Acquisition of the LUMICKS Avidion analyzer will significantly enhance NIH- funded translational research efforts, driving innovative therapies from bench to bedside, ultimately benefiting public health through improved patient outcomes.
Grant Summary
Cell Avidity Measurement with the Lumicks Avidion to Evaluate the Effector T cell Function against Cancer is a OD - NIH Office of the Director grant providing up to $573K for university, nonprofit, healthcare org. Applications are due 2027-05-14 (open). Check eligibility and apply with FindGrants.
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Eligibility
How to Apply
Up to $573K
2027-05-14
- 1Confirm your organization is eligible for Cell Avidity Measurement with the Lumicks Avidion to Evaluate the Effector T cell Function against Cancer from OD - NIH Office of the Director, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to OD - NIH Office of the Director before the deadline.
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Cell Avidity Measurement with the Lumicks Avidion to Evaluate the Effector T cell Function against Cancer: Frequently Asked Questions
Who is eligible for the Cell Avidity Measurement with the Lumicks Avidion to Evaluate the Effector T cell Function against Cancer?
Cell Avidity Measurement with the Lumicks Avidion to Evaluate the Effector T cell Function against Cancer is offered by OD - NIH Office of the Director and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Cell Avidity Measurement with the Lumicks Avidion to Evaluate the Effector T cell Function against Cancer provide?
Cell Avidity Measurement with the Lumicks Avidion to Evaluate the Effector T cell Function against Cancer provides up to $573K per award from OD - NIH Office of the Director. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Cell Avidity Measurement with the Lumicks Avidion to Evaluate the Effector T cell Function against Cancer deadline?
Applications for Cell Avidity Measurement with the Lumicks Avidion to Evaluate the Effector T cell Function against Cancer are due 2027-05-14 (open). Because deadlines can change, verify the date with the funder, OD - NIH Office of the Director, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Cell Avidity Measurement with the Lumicks Avidion to Evaluate the Effector T cell Function against Cancer?
To apply for Cell Avidity Measurement with the Lumicks Avidion to Evaluate the Effector T cell Function against Cancer, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from OD - NIH Office of the Director.