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View full policySchottky Field Emission Scanning Electron Microscope (FESEM) with serial block-face imaging for a multi user core imaging facility
OD - NIH Office of the Director
About This Grant
PROJECT SUMMARY/ABSTRACT This application is a shared instrumentation grant from the Analytical Imaging Facility (AIF) at the Albert Einstein College of Medicine to acquire a new, advanced field emission scanning electron microscope (FE-SEM) with the ability to perform serial block-face imaging (SBF-SEM). The AIF supports many investigators at Einstein (143 Principal Investigator Laboratories in 2024), including many NIH funded investigators, by giving them access to state-of-the-art microscopy technologies that enhance cutting edge, collaborative, and multidisciplinary research. Since 2011, the AIF has had a Zeiss scanning electron microscope capable of 3D volume imaging with a total usage of 1987 hours from January 2024 through August 2024. Due to the age of the instrument, we have only been able to have a limited service contract on the microscope since 2023. This means that the vendor no longer guarantees availability of parts as part of the contract. The microscope had a component failure in September 2024 that the vendor has been unable to repair due to inability to obtain replacement parts. To continue to support the ongoing NIH funded biomedical research that relies on scanning electron microscopy, we need to replace the failed instrument with a new FE-SEM that can offer all the functions of our failed current microscope, including secondary electron imaging for fine surface detail as well as the capability of 3D volume reconstruction. For 3D volume imaging, the requested microscope has the capability of serial block face imaging. In this method, the sample surface is imaged, then a thin slice is removed, then the next image is acquired, resulting in the serial acquisition of a z-stack of the sample. The AIF has ongoing 3D volume projects for all the Major Users in this application. New image acquisition has been halted since the microscope has been down for 8 months. During this period, the AIF staff have been concentrating on image analysis of the collected data by developing expertise in segmentation and presentation of 3D models. A new microscope is urgently needed to enable these projects to move forward. Overall, acquisition of this advanced instrument will have a high impact on the NIH-funded biomedical research at Einstein, including the following major and minor user projects: fine structural aspects of atherosclerosis (Dr. Raiscos-Bernal), cardiovascular disease (Dr. Sibinga), spermatogenesis (Dr. Jenny), cellular response of cytotoxic chemotherapy on lymphoid organs (Dr. Karagiannis), autophagy (Dr. Singh), neurodegenerative disease (Dr. Willis) and diabetes (Dr. Santulli). There are also additional four minor user projects and 6+ labs currently using traditional (secondary electron surface imaging) scanning electron microscopy here at Einstein that will benefit from this technology.
Grant Summary
Schottky Field Emission Scanning Electron Microscope (FESEM) with serial block-face imaging for a multi user core imaging facility is a OD - NIH Office of the Director grant providing up to $750K for university, nonprofit, healthcare org. Applications are due 2027-05-15 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $750K
2027-05-15
- 1Confirm your organization is eligible for Schottky Field Emission Scanning Electron Microscope (FESEM) with serial block-face imaging for a multi user core imaging facility from OD - NIH Office of the Director, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to OD - NIH Office of the Director before the deadline.
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Schottky Field Emission Scanning Electron Microscope (FESEM) with serial block-face imaging for a multi user core imaging facility: Frequently Asked Questions
Who is eligible for the Schottky Field Emission Scanning Electron Microscope (FESEM) with serial block-face imaging for a multi user core imaging facility?
Schottky Field Emission Scanning Electron Microscope (FESEM) with serial block-face imaging for a multi user core imaging facility is offered by OD - NIH Office of the Director and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Schottky Field Emission Scanning Electron Microscope (FESEM) with serial block-face imaging for a multi user core imaging facility provide?
Schottky Field Emission Scanning Electron Microscope (FESEM) with serial block-face imaging for a multi user core imaging facility provides up to $750K per award from OD - NIH Office of the Director. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Schottky Field Emission Scanning Electron Microscope (FESEM) with serial block-face imaging for a multi user core imaging facility deadline?
Applications for Schottky Field Emission Scanning Electron Microscope (FESEM) with serial block-face imaging for a multi user core imaging facility are due 2027-05-15 (open). Because deadlines can change, verify the date with the funder, OD - NIH Office of the Director, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Schottky Field Emission Scanning Electron Microscope (FESEM) with serial block-face imaging for a multi user core imaging facility?
To apply for Schottky Field Emission Scanning Electron Microscope (FESEM) with serial block-face imaging for a multi user core imaging facility, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from OD - NIH Office of the Director.