NIH AI Restriction
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View full policyX-RAD 320 with OptiMax
OD - NIH Office of the Director
About This Grant
PROJECT SUMMARY/ABSTRACT The Division of Translational Radiation Sciences (DTRS) was established to accelerate the discovery and clinical implementation of new therapeutic strategies in clinical radiotherapy at the University of Maryland School of Medicine. DTRS and the Department of Radiation Oncology have been at the forefront of this field for several decades, having been one of the first institutions to secure a Medical Countermeasures Against Radiological Threats (MCART) consortium award from the NIH in 2005. DTRS currently leads two NIH-sponsored consortia: the Intercollaborative Radiation Countermeasures (INTERACT) Consortium (5U19AI150574-05), and the Radiation Oncology-Biology Integration Network on Oligometastasis (ROBIN OligoMET, 5U54CA273956-03). Our experienced physicists perform both in vitro and in vivo irradiations (in small and large animals) for investigators involved in these two consortia, as well as for other researchers requiring precise and accurate delivery of radiation doses in their experiments. DTRS is not a core facility but operates on a fee-for-service basis to perform and support these procedures for investigators across campus. A large number of our users rely on our current XRAD-320 X-ray irradiator, which has become increasingly unreliable, as the manufacturer no longer services the power generator or offers preventive maintenance, making future repairs potentially impossible. Our department also utilizes cesium-137 irradiators that must be phased out to comply with the U.S. Congress–mandated National Defense Authorization Act (NDAA), which calls for the elimination of all cesium- based irradiators in the U.S. by December 31, 2027, to mitigate national security risks associated with high- activity radioactive sources. We are therefore proposing to replace our aging and unsupported irradiator technology with a modern X-RAD 320 equipped with OptiMAX imaging. This state-of-the-art instrument offers advanced imaging capabilities, enabling precise targeting of radiation delivery to biological tissues. It will support current studies with improved accuracy, allow for the development of new experimental designs, and reduce labor requirements for existing protocols. Additionally, this system is considered one of the most suitable replacements for Cs-137 gamma irradiators. We have identified a group of NIH-funded users within the University of Maryland who rely on the current system or who would benefit from expanded capacity beyond what our aging platform can reliably support. Many of the research projects described in this application are translational in nature and aim to accelerate the understanding of disease mechanisms and the development of novel therapeutic strategies. Our institution is committed to providing substantial support for the installation and long-term operation of this system. The management and operational infrastructure are already in place, led by an outstanding technical team dedicated to delivering high-quality service to all users.
Grant Summary
X-RAD 320 with OptiMax is a OD - NIH Office of the Director grant providing up to $418K for university, nonprofit, healthcare org. Applications are due 2027-04-30 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $418K
2027-04-30
- 1Confirm your organization is eligible for X-RAD 320 with OptiMax from OD - NIH Office of the Director, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to OD - NIH Office of the Director before the deadline.
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X-RAD 320 with OptiMax: Frequently Asked Questions
Who is eligible for the X-RAD 320 with OptiMax?
X-RAD 320 with OptiMax is offered by OD - NIH Office of the Director and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the X-RAD 320 with OptiMax provide?
X-RAD 320 with OptiMax provides up to $418K per award from OD - NIH Office of the Director. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the X-RAD 320 with OptiMax deadline?
Applications for X-RAD 320 with OptiMax are due 2027-04-30 (open). Because deadlines can change, verify the date with the funder, OD - NIH Office of the Director, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the X-RAD 320 with OptiMax?
To apply for X-RAD 320 with OptiMax, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from OD - NIH Office of the Director.