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View full policyOrbitrap Ascend Tribrid Mass Spectrometer System for Advancing Proteomics Research in Southeastern Wisconsin
About This Grant
This resubmission requests funds under the NIH S10 High-End Instrumentation (HEI) Program to acquire a Thermo Scientific Orbitrap Ascend Tribrid mass spectrometer (Ascend MS), coupled with a Vanquish Neo UHPLC system, for installation in the Translational Metabolomics Shared Resource (TraM SR) Mass Spectrometry Core (MS Core) at the Medical College of Wisconsin (MCW). The MS Core will relocate to a newly constructed facility within the Center for Cancer Discovery, scheduled for completion in August 2025. To reflect the refined scope, the project title has changed from Tribrid Ascend Mass Spectrometer for Accelerating MultiOmics Research to Orbitrap Ascend Tribrid Mass Spectrometer System for Advancing Proteomics Research in Southeastern Wisconsin, emphasizing proteomics as the primary focus. The Ascend MS offers next-generation proteomics capabilities with high sensitivity, resolution, and acquisition speed. It supports ion activation methods including collision induced dissociation (CID), higher energy collisional dissociation (HCD), and electron transfer dissociation (ETD), along with ultraviolet photodissociation (UVPD), proton transfer charge reduction (PTCR), high mass range (HMRn), and the FAIMS Pro interface. These enable advanced analysis of intact proteins, post translational modifications, and low abundance targets, supporting diverse biomedical research programs. The Ascend MS will serve 19 NIH- funded investigators, including 9 Major Users with 17 active NIH awards (R01, P01, R35, T32), 9 Minor Users with 14 NIH grants (R01, R21, R35, R37, U54), and 6 Other Users including 1 with an R35. These investigators conduct high-impact research in cancer, inflammation, cardiovascular disease, infectious disease, neuroscience, pregnancy, and structural biology. The system’s ultra-low volume capabilities and advanced Orbitrap workflows will enable deep proteome profiling and high-resolution analyses, accelerating discoveries in disease mechanisms and therapeutics. The instrument will be operated and maintained by the MS Core, staffed by experienced personnel. A new full-time scientist joined on April 7, 2025, and an additional staff member will be recruited after acquisition. Operational infrastructure includes the iLab scheduling and billing platform, an advisory committee, and administrative oversight by the MCW Cancer Center’s senior business administrator. The Ascend MS will be fully utilized for fee-for-service projects, supporting NIH-funded and other researchers at MCW and partner institutions. The MCW Cancer Center has committed to subsidizing 50% of proteomics costs, ensuring affordability and broad access. The fee structure will be reviewed annually based on user surveys to maintain accessibility and responsiveness. Acquisition of the Ascend MS will transform NIH-funded research at MCW and its regional partners in southeastern Wisconsin. This state-of-the-art system will advance scientific discovery and align with the NIH mission to improve human health through cutting-edge proteomics research.
Grant Summary
Orbitrap Ascend Tribrid Mass Spectrometer System for Advancing Proteomics Research in Southeastern Wisconsin is a OD - NIH Office of the Director grant providing up to $1.5M for university, nonprofit, healthcare org. Applications are due 2027-07-31 (open). Check eligibility and apply with FindGrants.
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Focus Areas
Eligibility
How to Apply
Up to $1.5M
2027-07-31
- 1Confirm your organization is eligible for Orbitrap Ascend Tribrid Mass Spectrometer System for Advancing Proteomics Research in Southeastern Wisconsin from OD - NIH Office of the Director, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to OD - NIH Office of the Director before the deadline.
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Orbitrap Ascend Tribrid Mass Spectrometer System for Advancing Proteomics Research in Southeastern Wisconsin: Frequently Asked Questions
Who is eligible for the Orbitrap Ascend Tribrid Mass Spectrometer System for Advancing Proteomics Research in Southeastern Wisconsin?
Orbitrap Ascend Tribrid Mass Spectrometer System for Advancing Proteomics Research in Southeastern Wisconsin is offered by OD - NIH Office of the Director and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Orbitrap Ascend Tribrid Mass Spectrometer System for Advancing Proteomics Research in Southeastern Wisconsin provide?
Orbitrap Ascend Tribrid Mass Spectrometer System for Advancing Proteomics Research in Southeastern Wisconsin provides up to $1.5M per award from OD - NIH Office of the Director. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Orbitrap Ascend Tribrid Mass Spectrometer System for Advancing Proteomics Research in Southeastern Wisconsin deadline?
Applications for Orbitrap Ascend Tribrid Mass Spectrometer System for Advancing Proteomics Research in Southeastern Wisconsin are due 2027-07-31 (open). Because deadlines can change, verify the date with the funder, OD - NIH Office of the Director, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Orbitrap Ascend Tribrid Mass Spectrometer System for Advancing Proteomics Research in Southeastern Wisconsin?
To apply for Orbitrap Ascend Tribrid Mass Spectrometer System for Advancing Proteomics Research in Southeastern Wisconsin, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from OD - NIH Office of the Director.