Validation of [18F]3F4AP PET for Detecting and Quantifying Peripheral Nerve Injuries
NINDS - National Institute of Neurological Disorders and Stroke
About This Grant
SUMMARY Peripheral nerve injuries (PNIs) are surprisingly common, yet effective and reliable biomarkers for their diagnosis and prognosis remain an unmet clinical need. Traditional clinical examinations, standard neurophysiological tests, and current imaging methods often lack objectivity, depend heavily on clinician expertise, and have limited prognostic value. To address this gap, we propose a phased R61/R33 study to develop and validate [18F]3F4AP, a novel PET radioligand, as a biomarker for PNIs. In the R61 phase, we will test the hypothesis that [18F]3F4AP—an investigational PET tracer available at Massachusetts General Hospital for human research—can reliably detect overexpressed potassium channels in demyelinated axons, a hallmark of incomplete PNIs. Specifically, we will evaluate the pharmacokinetics and imaging protocols of this tracer in patients with upper or lower limb PNIs, radiculopathies, and plexus injuries, using state-of-the-art PET/MRI and high-resolution, high-sensitivity organ-specific PET scanners. This phase aims to establish optimal imaging parameters and assess the tracer’s initial diagnostic accuracy in well-characterized incomplete PNIs. In the R33 phase, we will expand the study to include a broader patient cohort, including individuals with PNIs of uncertain diagnosis or prognosis. This phase will focus on validating the radioligand’s ability to detect PNIs across a range of severities and chronicities and will assess whether [¹⁸F]3F4AP PET offers superior diagnostic performance compared to existing tools. By the conclusion of the R33 phase, we aim to establish [¹⁸F]3F4AP PET as a reliable diagnostic modality for PNIs, positioning it for further analytical and clinical validation. This project addresses a critical need for improved PNI diagnostics, with the potential to reduce unnecessary surgeries, enhance treatment planning, and ultimately improve patient outcomes, making a significant impact on public health.
Grant Summary
Validation of [18F]3F4AP PET for Detecting and Quantifying Peripheral Nerve Injuries is a NINDS - National Institute of Neurological Disorders and Stroke grant providing up to $2.0M for university, nonprofit, healthcare org. Applications are due 2029-06-30 (open). Check eligibility and apply with FindGrants.
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Up to $2.0M
2029-06-30
- 1Confirm your organization is eligible for Validation of [18F]3F4AP PET for Detecting and Quantifying Peripheral Nerve Injuries from NINDS - National Institute of Neurological Disorders and Stroke, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NINDS - National Institute of Neurological Disorders and Stroke before the deadline.
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Validation of [18F]3F4AP PET for Detecting and Quantifying Peripheral Nerve Injuries: Frequently Asked Questions
Who is eligible for the Validation of [18F]3F4AP PET for Detecting and Quantifying Peripheral Nerve Injuries?
Validation of [18F]3F4AP PET for Detecting and Quantifying Peripheral Nerve Injuries is offered by NINDS - National Institute of Neurological Disorders and Stroke and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Validation of [18F]3F4AP PET for Detecting and Quantifying Peripheral Nerve Injuries provide?
Validation of [18F]3F4AP PET for Detecting and Quantifying Peripheral Nerve Injuries provides up to $2.0M per award from NINDS - National Institute of Neurological Disorders and Stroke. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Validation of [18F]3F4AP PET for Detecting and Quantifying Peripheral Nerve Injuries deadline?
Applications for Validation of [18F]3F4AP PET for Detecting and Quantifying Peripheral Nerve Injuries are due 2029-06-30 (open). Because deadlines can change, verify the date with the funder, NINDS - National Institute of Neurological Disorders and Stroke, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Validation of [18F]3F4AP PET for Detecting and Quantifying Peripheral Nerve Injuries?
To apply for Validation of [18F]3F4AP PET for Detecting and Quantifying Peripheral Nerve Injuries, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NINDS - National Institute of Neurological Disorders and Stroke.