Development and Pilot Testing of a Novel Treatment Intervention for Dual Substance Use Disorder (DUD) in Heterosexual Couples
About This Grant
PROJECT SUMMARY Drug use disorders (DUDs), a subclassification of substance use disorders (SUDs) involving the misuse of non-alcohol illicit drugs, remain a major public health crisis in the U.S., affecting 27 million persons and contributing to over 100,000 overdose deaths annually. Among those with DUDs, 30% to 50% have a primary sexual partner who also has a DUD—dual-DUD couples. These couples experience significantly poorer treatment outcomes, including higher relapse rates and lower treatment engagement, compared to individuals without a drug-using partner. Despite the well-documented reciprocal influence of partners on each other’s substance use, current treatment paradigms remain predominantly individual-focused, overlooking the relational context in which substance use and recovery occur. The absence of couples-based treatment models designed specifically for dual-DUD couples represents a critical gap in the addiction treatment landscape. This study aims to address this gap by developing and piloting a novel couples-based intervention tailored to the needs of dual-DUD couples who use opioids and/or stimulants. Grounded in the Recovery Capital framework and the SUD Couple System model, this study will incorporate a Co-Creation approach to intervention development, ensuring meaningful engagement from stakeholders, including affected couples, treatment providers, and administrators. The research design follows an R61/R33 phased structure, integrating the Intervention Mapping + Adapt (IMA) framework for intervention development with the Consolidated Framework for Implementation Research (CFIR) to guide and evaluate implementation strategies. In the R61 phase, formative mixed-methods research will be conducted to identify key determinants and recovery assets influencing drug use behavior and treatment outcomes among dual-DUD couples (Aim 1). These findings will inform the development and adaptation of a couples-based treatment program using an intervention mapping approach (Aim 2). The R33 phase will involve finalizing intervention materials and implementation strategies (Aim 3), conducting a dual-site pilot randomized controlled trial (RCT) at SUD treatment centers in Rochester, NY, and Newark, NJ (Aim 4), and evaluating post-pilot data to refine the intervention and assess readiness for a confirmatory Hybrid Type 2 effectiveness trial (Aim 5). This project aligns with the objectives of RFA DA-26-024 (R61/R33 Exploratory/Developmental Phased Award), which seeks to engage loved ones in the recovery process and enhance access to evidence-based care for those affected by DUDs. develop and test dyadic approaches to support engagement in evidence-based care for individuals in DUD-affected relationships. By addressing a longstanding treatment gap, this study aims to contribute to the broader goal of reducing substance use-related harm and improving public health through innovative, relationship-centered care models.
Grant Summary
Development and Pilot Testing of a Novel Treatment Intervention for Dual Substance Use Disorder (DUD) in Heterosexual Couples is a NIDA - National Institute on Drug Abuse grant providing up to $433K for university, nonprofit, healthcare org. Applications are due 2028-02-28 (open). Check eligibility and apply with FindGrants.
Not quite the right fit?
Search 9,000+ open grants, or get matches ranked for your organization — free.
Focus Areas
Eligibility
How to Apply
Up to $433K
2028-02-28
- 1Confirm your organization is eligible for Development and Pilot Testing of a Novel Treatment Intervention for Dual Substance Use Disorder (DUD) in Heterosexual Couples from NIDA - National Institute on Drug Abuse, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIDA - National Institute on Drug Abuse before the deadline.
Don't want to draft it yourself?
We'll draft the complete application against NIDA - National Institute on Drug Abuse's requirements, run a quality review, and email you a submission-ready PDF plus an editable Word doc within 5 business days. Most orders deliver in 24-48 hours. Flat $399, any grant size.
AI Requirement Analysis
Detailed requirements not yet analyzed
Have the NOFO? Paste it below for AI-powered requirement analysis.
Development and Pilot Testing of a Novel Treatment Intervention for Dual Substance Use Disorder (DUD) in Heterosexual Couples: Frequently Asked Questions
Who is eligible for the Development and Pilot Testing of a Novel Treatment Intervention for Dual Substance Use Disorder (DUD) in Heterosexual Couples?
Development and Pilot Testing of a Novel Treatment Intervention for Dual Substance Use Disorder (DUD) in Heterosexual Couples is offered by NIDA - National Institute on Drug Abuse and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Development and Pilot Testing of a Novel Treatment Intervention for Dual Substance Use Disorder (DUD) in Heterosexual Couples provide?
Development and Pilot Testing of a Novel Treatment Intervention for Dual Substance Use Disorder (DUD) in Heterosexual Couples provides up to $433K per award from NIDA - National Institute on Drug Abuse. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Development and Pilot Testing of a Novel Treatment Intervention for Dual Substance Use Disorder (DUD) in Heterosexual Couples deadline?
Applications for Development and Pilot Testing of a Novel Treatment Intervention for Dual Substance Use Disorder (DUD) in Heterosexual Couples are due 2028-02-28 (open). Because deadlines can change, verify the date with the funder, NIDA - National Institute on Drug Abuse, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Development and Pilot Testing of a Novel Treatment Intervention for Dual Substance Use Disorder (DUD) in Heterosexual Couples?
To apply for Development and Pilot Testing of a Novel Treatment Intervention for Dual Substance Use Disorder (DUD) in Heterosexual Couples, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIDA - National Institute on Drug Abuse.