Role of adipocyte interferon regulatory factor 8 in adipocyte and systemic metabolism and diet-induced obesity
NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases
About This Grant
If there is no change, enter No changes to the abstract or NONE. Adipocyte dyfuntion results in reduced BAT thermogenesis, low-grade chronic inflammation, fatty liver, and systemic insulin resistance. Still poorly understood are the mechanisms that trigger diet-induced obesity-associated adipocyte dysfunction. Our studies have identified that the transcription factor, interferon regulatory factor 8 (IRF8) is expressed constitutively in adipocytes of mice fed a low fat diet and when mice are fed a high fat diet (HFD) IRF8 expression is increased in white adipose tissue and brown adipose tissue adipocytes. Our preliminary studies position adipocyte IRF8 as an important transiption factor regulating brown and white adipocyte gene expression and metabolism, insulin resistance and diet-induced obesity and associated metabolic complications. Our goal is to ultimately define the specific role of IRF8 in white and brown adipocytes on adipocyte and systemic metabolism in mice fed a low fat and high fat diet to induce diet-induced obesity
Grant Summary
Role of adipocyte interferon regulatory factor 8 in adipocyte and systemic metabolism and diet-induced obesity is a NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases grant providing up to $232K for university, nonprofit, healthcare org. Applications are due 2027-02-28 (open). Check eligibility and apply with FindGrants.
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How to Apply
Up to $232K
2027-02-28
- 1Confirm your organization is eligible for Role of adipocyte interferon regulatory factor 8 in adipocyte and systemic metabolism and diet-induced obesity from NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases before the deadline.
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Role of adipocyte interferon regulatory factor 8 in adipocyte and systemic metabolism and diet-induced obesity: Frequently Asked Questions
Who is eligible for the Role of adipocyte interferon regulatory factor 8 in adipocyte and systemic metabolism and diet-induced obesity?
Role of adipocyte interferon regulatory factor 8 in adipocyte and systemic metabolism and diet-induced obesity is offered by NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Role of adipocyte interferon regulatory factor 8 in adipocyte and systemic metabolism and diet-induced obesity provide?
Role of adipocyte interferon regulatory factor 8 in adipocyte and systemic metabolism and diet-induced obesity provides up to $232K per award from NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Role of adipocyte interferon regulatory factor 8 in adipocyte and systemic metabolism and diet-induced obesity deadline?
Applications for Role of adipocyte interferon regulatory factor 8 in adipocyte and systemic metabolism and diet-induced obesity are due 2027-02-28 (open). Because deadlines can change, verify the date with the funder, NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Role of adipocyte interferon regulatory factor 8 in adipocyte and systemic metabolism and diet-induced obesity?
To apply for Role of adipocyte interferon regulatory factor 8 in adipocyte and systemic metabolism and diet-induced obesity, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases.