The Role of nBMP2 in Macrophage Oral Immunomodulation
NIDCR - National Institute of Dental and Craniofacial Research
About This Grant
Abstract Periodontal regeneration and bone repair involve classical elements of wound healing and have been perennially met with challenges of inconsistency and predictability. Among the gaps in knowledge regarding periodontal regeneration is how macrophage polarization and function influence periodontal regeneration and bone repair. We and others have defined a central role for the macrophage in the successful regeneration of bone and the periodontium. However, there remains an undefined role for bone morphogenetic protein 2 (BMP2) and nuclear BMP2 – an under characterized BMP2 isoform – in macrophage immunomodulation that supports successful regeneration. We have observed extensive nuclear localization of BMP2 in macrophages cultured on nanoscale topographies and noted that nuclear BMP2-positive macrophages have an M2-like (regenerative) phenotype. In addition, nBMP2 knockout leads to a decrease in STAT6 expression in macrophages and an increase in ligature-induced periodontal bone loss. Combined with Alphafold 3 predictive results and our initial immunoprecipitation data, we will investigate the overarching hypothesis that macrophage nBMP2 and BMP2 expression positively influences macrophage M2 polarization and tissue regeneration via modulation of STAT6 activity. The specific aims are: AIM 1: to characterize the regulation of macrophage nBMP2/BMP2 expression. AIM 2: to functionally dissect nBMP2-regulated STAT6 signaling pathways in macrophages. AIM 3: to demonstrate the role of macrophage nBMP2/BMP2 on tissue repair and regeneration. Using cell culture and knockout mouse models of macrophage nBMP2 and BMP2 expression, and defined models of periodontal regeneration and bone repair, the present study will define the mechanism by which nuclear BMP2 controls macrophage polarization and how macrophage nBMP2/BMP2 expression contributes to bone and periodontal regeneration. The proposed mechanistic studies will be critical for understanding how macrophages contribute to immunomodulation in tissue regeneration, particularly in periodontal regeneration and bone repair. Furthermore, new insights into the physiologic regulation of macrophage function and polarization can extend beyond periodontal regeneration to other tissues, as well as their role in cancer as tissue-associated macrophages.
Grant Summary
The Role of nBMP2 in Macrophage Oral Immunomodulation is a NIDCR - National Institute of Dental and Craniofacial Research grant providing up to $311K for university, nonprofit, healthcare org. Applications are due 2027-06-14 (open). Check eligibility and apply with FindGrants.
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Up to $311K
2027-06-14
- 1Confirm your organization is eligible for The Role of nBMP2 in Macrophage Oral Immunomodulation from NIDCR - National Institute of Dental and Craniofacial Research, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
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The Role of nBMP2 in Macrophage Oral Immunomodulation: Frequently Asked Questions
Who is eligible for the The Role of nBMP2 in Macrophage Oral Immunomodulation?
The Role of nBMP2 in Macrophage Oral Immunomodulation is offered by NIDCR - National Institute of Dental and Craniofacial Research and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the The Role of nBMP2 in Macrophage Oral Immunomodulation provide?
The Role of nBMP2 in Macrophage Oral Immunomodulation provides up to $311K per award from NIDCR - National Institute of Dental and Craniofacial Research. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the The Role of nBMP2 in Macrophage Oral Immunomodulation deadline?
Applications for The Role of nBMP2 in Macrophage Oral Immunomodulation are due 2027-06-14 (open). Because deadlines can change, verify the date with the funder, NIDCR - National Institute of Dental and Craniofacial Research, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the The Role of nBMP2 in Macrophage Oral Immunomodulation?
To apply for The Role of nBMP2 in Macrophage Oral Immunomodulation, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIDCR - National Institute of Dental and Craniofacial Research.