Design of rapid and quantitative biosensors with computational protein design
About This Grant
Project Summary Monod Bio’s Fast-Track proposal aims to advance the NovoLISA™ technology, transforming biosensing methods in Life Sciences research. Traditional biosensing approaches, such as ELISAs, face significant limitations, including prolonged time-to-results (90–270 minutes), complex procedures, extensive antibody development times, and the risk of cross-reactivity due to insufficient antibody validation. In contrast, Monod Bio’s NovoLISA assay offers a rapid (<15 minutes), single-step, no-wash solution that utilizes computationally designed proteins (NovoBodies) as reagents. NovoBodies serve as effective alternatives to traditional antibodies, developed in just 4-5 weeks, and are used in assays powered by Monod Bio’s proprietary split luciferase system, LuxSit Pro™. This system enables quick, accurate biomarker detection via luminescence using standard plate readers, which are widely available in research labs. Monod Bio has already developed a sensitive NovoLISA assay for C-reactive protein (CRP) and is working on additional assays for key biomarkers, including IL-6, TNF-α, and PSA. Phase I of this project focuses on enhancing the sensitivity and adaptability of these assays for a broader range of laboratory environments, with specific goals to improve performance metrics such as limit of detection (LOD), time-to-result, and specificity. Phase II will expand the scope of research by developing assays for three new biomarkers—IL- 2, TSH, and VEGF—and optimizing them for use in complex biological matrices. Additionally, the project will include a pilot manufacturing study for quality control and will engage external laboratories for testing to ensure robustness and reproducibility across diverse research settings. At the conclusion of this proposal, Monod Bio will have developed up to six commercially ready assay kits that will significantly reduce assay times for researchers. Monod Bio will continue to expand the NovoLISA platform catalog of biomarker quantification kits. The goal of this Fast-Track proposal is to provide the scientific community—particularly immunology, oncology, and infectious disease research—with powerful, rapid, and sensitive tools for biomarker detection. Our NovoLISA technology has the potential to replace traditional biosensing methods like ELISA in research-use-only (RUO) settings, offering unparalleled efficiency, scalability, and precision. While this proposal focuses on (RUO) applications, we envision the NovoBody and NovoLISA platforms ultimately expanding into the In Vitro Diagnostics (IVD) space. As a testament of the anticipated impact, Monod Bio was recently awarded a $1.5 million grant from the Gates Foundation to develop next-generation tuberculosis diagnostics using the NovoBody platform, as well as a $750,000 grant to develop preeclampsia diagnostics leveraging the NovoLISA platform. This Fast-Track SBIR grant will enable us to demonstrate the impact of our NovoLISA platform in the RUO space, supporting a wide range of basic and clinical research efforts across academia and industry.
Grant Summary
Design of rapid and quantitative biosensors with computational protein design is a NIGMS - National Institute of General Medical Sciences grant providing up to $377K for university, nonprofit, healthcare org. Applications are due 2027-05-31 (open). Check eligibility and apply with FindGrants.
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How to Apply
Up to $377K
2027-05-31
- 1Confirm your organization is eligible for Design of rapid and quantitative biosensors with computational protein design from NIGMS - National Institute of General Medical Sciences, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIGMS - National Institute of General Medical Sciences before the deadline.
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Design of rapid and quantitative biosensors with computational protein design: Frequently Asked Questions
Who is eligible for the Design of rapid and quantitative biosensors with computational protein design?
Design of rapid and quantitative biosensors with computational protein design is offered by NIGMS - National Institute of General Medical Sciences and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Design of rapid and quantitative biosensors with computational protein design provide?
Design of rapid and quantitative biosensors with computational protein design provides up to $377K per award from NIGMS - National Institute of General Medical Sciences. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Design of rapid and quantitative biosensors with computational protein design deadline?
Applications for Design of rapid and quantitative biosensors with computational protein design are due 2027-05-31 (open). Because deadlines can change, verify the date with the funder, NIGMS - National Institute of General Medical Sciences, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Design of rapid and quantitative biosensors with computational protein design?
To apply for Design of rapid and quantitative biosensors with computational protein design, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIGMS - National Institute of General Medical Sciences.