A Novel Human Intestinal Organoid Platform with Peristaltic Function for Drug Discovery and Pre-Clinical Testing in GI Motility Disorders
NCATS - National Center for Advancing Translational Sciences
About This Grant
ABSTRACT Gastrointestinal (GI) motility disorders such as irritable bowel syndrome and inflammatory bowel disease impose substantial medical and economic burdens, yet drug development remains hampered by preclinical models that fail to recapitulate human physiology and pathophysiology. Our long-term goal is to enable mechanism-informed discovery of safe and effective therapeutics by developing novel human models that accurately reflect human biology. The overall objective of this Phase I SBIR is to establish, validate, and deploy a scalable human peristaltic intestinal organoid (peristaltic-HIO) platform that couples quantitative functional readouts with deep molecular and cellular profiling. Our strong preliminary data shows self-organized peristaltic activity in pluripotent stem cell–derived HIOs containing the enteric nerons, smooth muscle, interstitial cells of Cajal, epithelium, and endothelium, and on our automated live-imaging pipeline for contraction frequency, amplitude, and coordination. We will integrate organ-level quantitative peristalsis measurements with high- content imaging and single-nucleus transcriptomics, yielding multimodal “fingerprints” that both reveal drug mechanisms and that will power predictive models for efficacy and GI-specific toxicity. We will pursue two aims: Aim 1—Engineer and rigorously validate peristaltic-HIOs for 96-well scalability, reproducibility, and cellular fidelity using design-of-experiments optimization and single-cell/spatial QC signatures. Aim 2—Establish a quantitative, screen-ready peristalsis assay and benchmark pharmacologic responsiveness to canonical neuromuscular modulators to define assay dynamic range and acceptance criteria. At the end of Phase I, we will have a validated human peristalsis model with locked manufacturing and QC, a reference pharmacology panel and assay performance metrics suitable for discovery, and an integrated “HIO atlas” and predictive models that accelerate hit identification, repurposing, and lead optimization.
Grant Summary
A Novel Human Intestinal Organoid Platform with Peristaltic Function for Drug Discovery and Pre-Clinical Testing in GI Motility Disorders is a NCATS - National Center for Advancing Translational Sciences grant providing up to $350K for university, nonprofit, healthcare org. Applications are due 2027-07-14 (open). Check eligibility and apply with FindGrants.
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How to Apply
Up to $350K
2027-07-14
- 1Confirm your organization is eligible for A Novel Human Intestinal Organoid Platform with Peristaltic Function for Drug Discovery and Pre-Clinical Testing in GI Motility Disorders from NCATS - National Center for Advancing Translational Sciences, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NCATS - National Center for Advancing Translational Sciences before the deadline.
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A Novel Human Intestinal Organoid Platform with Peristaltic Function for Drug Discovery and Pre-Clinical Testing in GI Motility Disorders: Frequently Asked Questions
Who is eligible for the A Novel Human Intestinal Organoid Platform with Peristaltic Function for Drug Discovery and Pre-Clinical Testing in GI Motility Disorders?
A Novel Human Intestinal Organoid Platform with Peristaltic Function for Drug Discovery and Pre-Clinical Testing in GI Motility Disorders is offered by NCATS - National Center for Advancing Translational Sciences and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the A Novel Human Intestinal Organoid Platform with Peristaltic Function for Drug Discovery and Pre-Clinical Testing in GI Motility Disorders provide?
A Novel Human Intestinal Organoid Platform with Peristaltic Function for Drug Discovery and Pre-Clinical Testing in GI Motility Disorders provides up to $350K per award from NCATS - National Center for Advancing Translational Sciences. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the A Novel Human Intestinal Organoid Platform with Peristaltic Function for Drug Discovery and Pre-Clinical Testing in GI Motility Disorders deadline?
Applications for A Novel Human Intestinal Organoid Platform with Peristaltic Function for Drug Discovery and Pre-Clinical Testing in GI Motility Disorders are due 2027-07-14 (open). Because deadlines can change, verify the date with the funder, NCATS - National Center for Advancing Translational Sciences, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the A Novel Human Intestinal Organoid Platform with Peristaltic Function for Drug Discovery and Pre-Clinical Testing in GI Motility Disorders?
To apply for A Novel Human Intestinal Organoid Platform with Peristaltic Function for Drug Discovery and Pre-Clinical Testing in GI Motility Disorders, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NCATS - National Center for Advancing Translational Sciences.