Repurposing Glucagon-Like Peptide-1 Receptor Agonists for Mental Health Outcomes via Federated Causal Inference
About This Grant
Project Summary The proposed project addresses the need for reliable, privacy-preserving real-world evidence (RWE) on the potential mental health effects of glucagon-like peptide-1 receptor agonists (GLP-1 RAs). Although preliminary evidence suggests neuropsychiatric benefits, current observational studies are hindered by confounding, exposure misclassification, and institutional data-sharing barriers. These challenges are especially relevant in mental health research, where treatment timing and adherence are often uncertain. Aim 1 will develop a one- shot, lossless federated target trial emulation (TTE) framework that produces pooled-equivalent causal estimates using summary data. The model will integrate sequential trial emulation to address immortal time bias, likelihood- based exposure correction, and calibration via negative control outcomes. Summary statistics will be computed locally and securely aggregated in a single communication round. Aim 2 will evaluate the framework using de- identified EHR data from Ividence and UTSW and deliver a prototype R package. The package will include tools for data preprocessing, federated estimation, and visualization, supporting scalable and reproducible use across sites. Feasibility will be assessed based on analytic performance, system usability, and concordance with benchmark evidence. This project will deliver a scalable, privacy-compliant solution for multi-site causal inference using EHR data. It will advance the generation of RWE for mental health drug repurposing and establish a foundation for future clinical research and commercialization.
Grant Summary
Repurposing Glucagon-Like Peptide-1 Receptor Agonists for Mental Health Outcomes via Federated Causal Inference is a NIMH - National Institute of Mental Health grant providing up to $315K for university, nonprofit, healthcare org. Applications are due 2027-07-31 (open). Check eligibility and apply with FindGrants.
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Eligibility
How to Apply
Up to $315K
2027-07-31
- 1Confirm your organization is eligible for Repurposing Glucagon-Like Peptide-1 Receptor Agonists for Mental Health Outcomes via Federated Causal Inference from NIMH - National Institute of Mental Health, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIMH - National Institute of Mental Health before the deadline.
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Repurposing Glucagon-Like Peptide-1 Receptor Agonists for Mental Health Outcomes via Federated Causal Inference: Frequently Asked Questions
Who is eligible for the Repurposing Glucagon-Like Peptide-1 Receptor Agonists for Mental Health Outcomes via Federated Causal Inference?
Repurposing Glucagon-Like Peptide-1 Receptor Agonists for Mental Health Outcomes via Federated Causal Inference is offered by NIMH - National Institute of Mental Health and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Repurposing Glucagon-Like Peptide-1 Receptor Agonists for Mental Health Outcomes via Federated Causal Inference provide?
Repurposing Glucagon-Like Peptide-1 Receptor Agonists for Mental Health Outcomes via Federated Causal Inference provides up to $315K per award from NIMH - National Institute of Mental Health. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Repurposing Glucagon-Like Peptide-1 Receptor Agonists for Mental Health Outcomes via Federated Causal Inference deadline?
Applications for Repurposing Glucagon-Like Peptide-1 Receptor Agonists for Mental Health Outcomes via Federated Causal Inference are due 2027-07-31 (open). Because deadlines can change, verify the date with the funder, NIMH - National Institute of Mental Health, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Repurposing Glucagon-Like Peptide-1 Receptor Agonists for Mental Health Outcomes via Federated Causal Inference?
To apply for Repurposing Glucagon-Like Peptide-1 Receptor Agonists for Mental Health Outcomes via Federated Causal Inference, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIMH - National Institute of Mental Health.