An indoor insecticide intervention to reduce allergen exposure and improve health outcomes for children with asthma in underserved communities
NIMHD - National Institute on Minority Health and Health Disparities
About This Grant
PROJECT SUMMARY / ABSTRACT Significance: Asthma is the most common chronic illness among American children, with exacerbation-related healthcare costs exceeding $21 billion annually. German cockroach exposure is a potent and independent trigger in sensitized children, eliciting IgE responses at lower concentrations than other indoor allergens. Expert Panel Reports, Asthma Management Guidelines, the NIH Inner-City Asthma Study, and multiple real-world studies support cockroach elimination strategies to improve asthma health outcomes in underserved communities. The Product: Deltamethrin (DM) is an active ingredient found in numerous commercial products, but all commercial solid formulations only contain the Form I crystal polymorph, which is widely ineffective against modern cockroach populations due to resistance. The SBIR product contains 0.05% amorphous DM, the most active solid form, adsorbed onto an inert and widely used powder. It is being developed as an allergen-specific intervention to improve asthma outcomes in underserved populations and will be sold as a cockroach-directed product. Innovation: Manipulating solid forms of contact insecticides to enhance activity is a commercially unexploited strategy that provides a novel approach to overcoming resistance and reducing asthma morbidity. Preliminary Studies: In response to reviewer critiques, PHD scientists developed a new, inexpensive method to make the product and demonstrated significantly improved lethality relative to a market-leading commercial benchmark when tested against both DM-susceptible (UCR) and field-collected DM-resistant (Ryan) strains of German cockroaches. An EPA pre-submission meeting confirmed the data requirements necessary to obtain an Experimental Use Permit (EUP) and conduct field testing, while an updated market analysis complimented National Science Foundation sponsored market research and confirmed the commercial feasibility of the product, with competitive pricing achievable using the new manufacturing process. The Long-Term Goal is the registration of the product to address a strategic priority of the NIMHD by targeting cockroach allergen exposure, an established primary driver of asthma morbidity in underserved communities. Specific Aim 1. Demonstrate the product performance of Enhanced Perlite against cockroaches to satisfy data requirements for an EUP. Studies will demonstrate the feasibility that the product is broadly efficacious against German cockroaches that are resistant to DM and commercial baits and satisfy EUP product performance data requirements. Success Criterion: Demonstration of a significant reduction in mean survival time for at least 3 of 5 resistant cockroach strains relative to a commercial benchmark. Expected Outcomes: Significant reduction in mean survival in ≥3 strains and 100% mortality by 72 h in all strains. Commercial Application: The initial market includes customers that purchase >500,000 pounds of DM- containing cockroach control powders annually, and peak annual revenues are projected at more than $20 mil.
Grant Summary
An indoor insecticide intervention to reduce allergen exposure and improve health outcomes for children with asthma in underserved communities is a NIMHD - National Institute on Minority Health and Health Disparities grant providing up to $314K for university, nonprofit, healthcare org. Applications are due 2027-07-31 (open). Check eligibility and apply with FindGrants.
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How to Apply
Up to $314K
2027-07-31
- 1Confirm your organization is eligible for An indoor insecticide intervention to reduce allergen exposure and improve health outcomes for children with asthma in underserved communities from NIMHD - National Institute on Minority Health and Health Disparities, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIMHD - National Institute on Minority Health and Health Disparities before the deadline.
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An indoor insecticide intervention to reduce allergen exposure and improve health outcomes for children with asthma in underserved communities: Frequently Asked Questions
Who is eligible for the An indoor insecticide intervention to reduce allergen exposure and improve health outcomes for children with asthma in underserved communities?
An indoor insecticide intervention to reduce allergen exposure and improve health outcomes for children with asthma in underserved communities is offered by NIMHD - National Institute on Minority Health and Health Disparities and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the An indoor insecticide intervention to reduce allergen exposure and improve health outcomes for children with asthma in underserved communities provide?
An indoor insecticide intervention to reduce allergen exposure and improve health outcomes for children with asthma in underserved communities provides up to $314K per award from NIMHD - National Institute on Minority Health and Health Disparities. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the An indoor insecticide intervention to reduce allergen exposure and improve health outcomes for children with asthma in underserved communities deadline?
Applications for An indoor insecticide intervention to reduce allergen exposure and improve health outcomes for children with asthma in underserved communities are due 2027-07-31 (open). Because deadlines can change, verify the date with the funder, NIMHD - National Institute on Minority Health and Health Disparities, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the An indoor insecticide intervention to reduce allergen exposure and improve health outcomes for children with asthma in underserved communities?
To apply for An indoor insecticide intervention to reduce allergen exposure and improve health outcomes for children with asthma in underserved communities, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIMHD - National Institute on Minority Health and Health Disparities.