A novel IDR-mediated interaction network linking chromatin state to RNA export
About This Grant
Project Summary Regulated export of RNA from the nucleus influences the stability, localization, and translation of nearly all cellular transcripts. Disruptions in RNA export are linked to neurodevelopmental disorders, neurodegeneration, and cancer, and several factors involved in RNA processing show promise as therapeutic targets. Although RNA export is strongly linked to transcriptional activity, the molecular mechanisms that link chromatin and transcriptional state to the recruitment, assembly, and spatial organization of the RNA export machinery are not fully understood. A major barrier to mechanistic insight is the unusually high abundance of intrinsically disordered regions (IDRs) in RNA export proteins. These flexible sequences evade conventional structural analyses but are increasingly recognized as key regulatory elements. As a result, the molecular and structural mechanisms by which IDRs in RNA export factors (1) ensure efficient export of highly transcribed genes, (2) facilitate the coordinated assembly of RNA export machinery, and (3) promote selective localization of RNA export factors into subnuclear foci remain to be elucidated. In preliminary studies, we uncovered a specific IDR-domain interaction that promotes RNA export by physically linking transcription export (TREX) complexes to chromatin state and subnuclear organization. Here we propose experiments using advanced tools in structural biology, epigenomics, chemical biology, and microscopy. Our proposed aims employ rapid manipulation of the involved activities in living cells to identify acute mechanisms. We have also designed rigorous assays that similarly measure immediate outcomes by analysis of nascent RNA, genomics, and live-cell microscopy. We will use these tools to answer essential questions, including: How is RNA export influenced by chromatin and transcription state? What is the structural basis for IDR-mediated regulation of RNA export? And how is the RNA export machinery spatially regulated in the nucleus? Our research will enhance understanding of fundamental principles of IDR-mediated regulation of RNA export, which may support emerging RNA-focused therapies.
Grant Summary
A novel IDR-mediated interaction network linking chromatin state to RNA export is a NIGMS - National Institute of General Medical Sciences grant providing up to $416K for university, nonprofit, healthcare org. Applications are due 2031-04-30 (open). Check eligibility and apply with FindGrants.
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How to Apply
Up to $416K
2031-04-30
- 1Confirm your organization is eligible for A novel IDR-mediated interaction network linking chromatin state to RNA export from NIGMS - National Institute of General Medical Sciences, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIGMS - National Institute of General Medical Sciences before the deadline.
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A novel IDR-mediated interaction network linking chromatin state to RNA export: Frequently Asked Questions
Who is eligible for the A novel IDR-mediated interaction network linking chromatin state to RNA export?
A novel IDR-mediated interaction network linking chromatin state to RNA export is offered by NIGMS - National Institute of General Medical Sciences and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the A novel IDR-mediated interaction network linking chromatin state to RNA export provide?
A novel IDR-mediated interaction network linking chromatin state to RNA export provides up to $416K per award from NIGMS - National Institute of General Medical Sciences. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the A novel IDR-mediated interaction network linking chromatin state to RNA export deadline?
Applications for A novel IDR-mediated interaction network linking chromatin state to RNA export are due 2031-04-30 (open). Because deadlines can change, verify the date with the funder, NIGMS - National Institute of General Medical Sciences, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the A novel IDR-mediated interaction network linking chromatin state to RNA export?
To apply for A novel IDR-mediated interaction network linking chromatin state to RNA export, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIGMS - National Institute of General Medical Sciences.