Deconstructing RNA polymerase III regulation and function
About This Grant
Project Summary / Abstract Deconstructing RNA polymerase III regulation and function RNA polymerase III (Pol III) transcription produces a plethora of noncoding (nc)RNAs essential for cell function and frequently dysregulated in contexts relevant to human health, including tRNAs, 5S rRNA, and small nuclear (sn)RNAs. Pol III activity is, itself, directly linked with modulating self-renewal and differentiation, and Pol III- derived ncRNAs individually promote cell proliferation and migration phenotypes via RNA-based mechanisms, altogether linking Pol III transcription dynamics and downstream small RNA landscapes to changes in cellular physiology. However, the full breadth of Pol III transcription and the mechanisms that shape tissue-specific patterns remain gaps in fundamental knowledge due to limited holistic studies of Pol III activity in cells. This proposal leverages a unique combination of genomic and biochemical strategies to systematically profile the breadth of Pol III activity and uncover new regulatory mechanisms - focusing first on a disease-associated Pol III subunit (RPC7a) and the Nucleosome Remodeling and Deacetylase (NuRD) complex. This cross-modality framework applies innovative genomic techniques, such as direct Pol III-4SU-UV-CLIP-nascent-seq and orthogonal analysis of Pol III-centered RNA chaperone protein La (SSB) ncRNA interactions, as well as traditional in vitro transcription tests to characterize both cellular and biochemical mechanisms. Determining the full range of Pol III transcription and the mechanisms contributing to context-specific Pol III regulation will have direct relevance to understanding Pol III dysregulation in cancer, infection, and other diseases, and will open new avenues for research on basic mechanisms of transcription regulation.
Grant Summary
Deconstructing RNA polymerase III regulation and function is a NIGMS - National Institute of General Medical Sciences grant providing up to $372K for university, nonprofit, healthcare org. Applications are due 2031-03-31 (open). Check eligibility and apply with FindGrants.
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Eligibility
How to Apply
Up to $372K
2031-03-31
- 1Confirm your organization is eligible for Deconstructing RNA polymerase III regulation and function from NIGMS - National Institute of General Medical Sciences, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIGMS - National Institute of General Medical Sciences before the deadline.
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Deconstructing RNA polymerase III regulation and function: Frequently Asked Questions
Who is eligible for the Deconstructing RNA polymerase III regulation and function?
Deconstructing RNA polymerase III regulation and function is offered by NIGMS - National Institute of General Medical Sciences and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Deconstructing RNA polymerase III regulation and function provide?
Deconstructing RNA polymerase III regulation and function provides up to $372K per award from NIGMS - National Institute of General Medical Sciences. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Deconstructing RNA polymerase III regulation and function deadline?
Applications for Deconstructing RNA polymerase III regulation and function are due 2031-03-31 (open). Because deadlines can change, verify the date with the funder, NIGMS - National Institute of General Medical Sciences, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Deconstructing RNA polymerase III regulation and function?
To apply for Deconstructing RNA polymerase III regulation and function, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIGMS - National Institute of General Medical Sciences.