UNDERSTUDIED NICHE PLAYERS GOVERNING TISSUE-SPECIFIC PROGENITORS
About This Grant
PROJECT SUMMARY Stem cells and progenitors are integral for tissue development, homeostasis and regeneration, and their dysfunction underlie development disorders, defective tissue regeneration, aging and cancer. In addition to intrinsic mechanisms, diverse niche cells influence stem/progenitor cell fate. Adult tissues harbor heterogenous stem/progenitor cell subsets which are intricately involved in tissue regeneration and disease. Yet, the fundamental cell types and molecular mechanisms that regulate distinct tissue-specific stem/progenitor cell populations remain poorly understood. Using the murine mammary gland as a model, we were the first to uncover primitive mesenchymal progenitor niche cells that have a remarkable capacity to contribute to a major subset of tissue-specific epithelial progenitors, indicating their potential role in replenishing progenitor cells central to tissue regeneration. We have also observed that sympathetic neurons modulate progenitor subsets in the niche and epithelium to orchestrate tissue regeneration. These niche cell types permeate diverse somatic tissues and thus, understanding their control of tissue-specific progenitors is critical for advancing progenitor- targeted therapies in regenerative medicine and malignancy. The proposed research will investigate how tissue-specific progenitor cell fate is dictated by mesenchymal progenitors and sympathetic neurons during adult tissue regeneration. We will utilize the postnatal mouse mammary gland as a tractable model to study tissue-specific progenitors given that it undergoes extensive morphogenesis directed by progenitors. We will explore niche cell-mediated modulation of progenitors and identify underlying molecular signals and mechanisms. We will employ a variety of strategies that include in vivo genetic reporter, lineage tracing and cell ablation mouse models and ex vivo organoids combined with phenotypic, functional assays and next-generation sequencing. Our findings will bridge key gaps in knowledge of the niche-driven circuitry that impacts tissue progenitors and provide a framework for improving the outcome of diseases attributed to aberrant progenitors.
Grant Summary
UNDERSTUDIED NICHE PLAYERS GOVERNING TISSUE-SPECIFIC PROGENITORS is a NIGMS - National Institute of General Medical Sciences grant providing up to $436K for university, nonprofit, healthcare org. Applications are due 2031-05-31 (open). Check eligibility and apply with FindGrants.
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Eligibility
How to Apply
Up to $436K
2031-05-31
- 1Confirm your organization is eligible for UNDERSTUDIED NICHE PLAYERS GOVERNING TISSUE-SPECIFIC PROGENITORS from NIGMS - National Institute of General Medical Sciences, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIGMS - National Institute of General Medical Sciences before the deadline.
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UNDERSTUDIED NICHE PLAYERS GOVERNING TISSUE-SPECIFIC PROGENITORS: Frequently Asked Questions
Who is eligible for the UNDERSTUDIED NICHE PLAYERS GOVERNING TISSUE-SPECIFIC PROGENITORS?
UNDERSTUDIED NICHE PLAYERS GOVERNING TISSUE-SPECIFIC PROGENITORS is offered by NIGMS - National Institute of General Medical Sciences and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the UNDERSTUDIED NICHE PLAYERS GOVERNING TISSUE-SPECIFIC PROGENITORS provide?
UNDERSTUDIED NICHE PLAYERS GOVERNING TISSUE-SPECIFIC PROGENITORS provides up to $436K per award from NIGMS - National Institute of General Medical Sciences. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the UNDERSTUDIED NICHE PLAYERS GOVERNING TISSUE-SPECIFIC PROGENITORS deadline?
Applications for UNDERSTUDIED NICHE PLAYERS GOVERNING TISSUE-SPECIFIC PROGENITORS are due 2031-05-31 (open). Because deadlines can change, verify the date with the funder, NIGMS - National Institute of General Medical Sciences, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the UNDERSTUDIED NICHE PLAYERS GOVERNING TISSUE-SPECIFIC PROGENITORS?
To apply for UNDERSTUDIED NICHE PLAYERS GOVERNING TISSUE-SPECIFIC PROGENITORS, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIGMS - National Institute of General Medical Sciences.