Bacterial stress responses mediated by c-di-AMP
About This Grant
Project Summary/Abstract Microorganisms employ diverse stress response systems to enable rapid and specific adaptations to environmental challenges such as antimicrobial stress, nutrient limitation, and osmotic pressure. The second messenger cyclic di-AMP (c-di-AMP) is produced by more than 11,000 bacterial and archaeal species, with its concentration fluctuating in response to these external stimuli and regulating carbon metabolism, osmotic homeostasis, cell wall synthesis, and DNA integrity. However, how bacteria translate external stimuli to c-di-AMP metabolism, as well as how c-di- AMP regulates bacterial physiology to alleviate cell stress remain poorly understood. Our recent findings reveal that elevated c-di-AMP production is associated with bacterial thymineless death regulation, a DNA damage-induced programmed cell death mechanism observed across all living cells. Additionally, we have identified c-di-AMP elevation as a conserved cell response to DNA damage across different Firmicutes, highlighting the importance of c-di-AMP as a global regulator for DNA integrity in bacteria. The long-term goal of our lab is to unravel previously undescribed bacterial stress response and adaptation mechanisms. The goal of this proposal is to investigate how early and late DNA damage signals, including DNA supercoil relaxation and DNA breaks, regulate c-di-AMP metabolism and how subsequent changes in c-di-AMP concentration influence nucleotide synthesis and salvage to facilitate DNA repair and inhibit cell death. By uncovering novel DNA integrity surveillance mechanisms, this foundational research will advance our understanding of bacterial stress responses and inform new strategies for developing antimicrobial targets.
Grant Summary
Bacterial stress responses mediated by c-di-AMP is a NIGMS - National Institute of General Medical Sciences grant providing up to $412K for university, nonprofit, healthcare org. Applications are due 2031-01-31 (open). Check eligibility and apply with FindGrants.
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How to Apply
Up to $412K
2031-01-31
- 1Confirm your organization is eligible for Bacterial stress responses mediated by c-di-AMP from NIGMS - National Institute of General Medical Sciences, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIGMS - National Institute of General Medical Sciences before the deadline.
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Bacterial stress responses mediated by c-di-AMP: Frequently Asked Questions
Who is eligible for the Bacterial stress responses mediated by c-di-AMP?
Bacterial stress responses mediated by c-di-AMP is offered by NIGMS - National Institute of General Medical Sciences and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Bacterial stress responses mediated by c-di-AMP provide?
Bacterial stress responses mediated by c-di-AMP provides up to $412K per award from NIGMS - National Institute of General Medical Sciences. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Bacterial stress responses mediated by c-di-AMP deadline?
Applications for Bacterial stress responses mediated by c-di-AMP are due 2031-01-31 (open). Because deadlines can change, verify the date with the funder, NIGMS - National Institute of General Medical Sciences, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Bacterial stress responses mediated by c-di-AMP?
To apply for Bacterial stress responses mediated by c-di-AMP, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIGMS - National Institute of General Medical Sciences.