Data-driven modeling of estrogen receptor
About This Grant
Abstract The estrogen receptor (ER or ERα) plays a fundamental role in breast cancer through complex molecular mechanisms involving its N-terminal transactivation domain (NTD), DNA-binding domain (DBD), and ligand- binding domain (LBD). Understanding their structural dynamics is crucial for developing next-generation ER- targeted therapeutics. Our research employs advanced biophysical techniques to decode two fundamental aspects of ER regulation. Project-1 will characterize the structural properties of the NTD through nuclear magnetic resonance spectroscopy and small-angle X-ray scattering (SAXS), generating comprehensive structural insights. Project-2 will examine the dynamic interactions between DBD and LBD using cryo-electron microscopy combined with solution-state SAXS analysis, revealing how various factors influence domain communication. These studies will establish a detailed framework for understanding ER regulation in normal and disease states, with broad implications for the nuclear receptor family. Our data-driven computational strategy will illuminate new molecular mechanisms underlying receptor function. The methodological advances from this research will enhance our understanding of protein dynamics and domain interactions across the nuclear receptor family, potentially leading to innovative therapeutic strategies for hormone-dependent cancers.
Grant Summary
Data-driven modeling of estrogen receptor is a NIGMS - National Institute of General Medical Sciences grant providing up to $432K for university, nonprofit, healthcare org. Applications are due 2031-02-28 (open). Check eligibility and apply with FindGrants.
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How to Apply
Up to $432K
2031-02-28
- 1Confirm your organization is eligible for Data-driven modeling of estrogen receptor from NIGMS - National Institute of General Medical Sciences, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIGMS - National Institute of General Medical Sciences before the deadline.
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Data-driven modeling of estrogen receptor: Frequently Asked Questions
Who is eligible for the Data-driven modeling of estrogen receptor?
Data-driven modeling of estrogen receptor is offered by NIGMS - National Institute of General Medical Sciences and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Data-driven modeling of estrogen receptor provide?
Data-driven modeling of estrogen receptor provides up to $432K per award from NIGMS - National Institute of General Medical Sciences. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Data-driven modeling of estrogen receptor deadline?
Applications for Data-driven modeling of estrogen receptor are due 2031-02-28 (open). Because deadlines can change, verify the date with the funder, NIGMS - National Institute of General Medical Sciences, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Data-driven modeling of estrogen receptor?
To apply for Data-driven modeling of estrogen receptor, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIGMS - National Institute of General Medical Sciences.