Defining Centriolar Plaque Architecture and Function Across Eukaryotic Diversity Using Expansion Microscopy and Proteomics
About This Grant
This research proposal aims to decode the structural and molecular architecture of centriolar plaques (CPs), a non-centrosomal microtubule organizing center, in the context of atypical eukaryotic cell division. Using expansion microscopy (U-ExM), we will map CP composition and dynamics with high resolution investigating their roles in MTOC formation, cell polarity, and organelle segregation during division. Our approach integrates U-ExM with functional analyses, leveraging CRISPR-Cas9 technology to generate inducible knockdown cell lines. This strategy will reveal the localizations and roles of key CP components, including taxon-specific and conserved proteins, in supporting nuclear division and cellular organization. By advancing our understanding of CP architecture and function, this work will provide transformative insights into conserved and divergent principles of eukaryotic cell division, offering a comparative framework to explore cellular diversity across eukaryotes.
Grant Summary
Defining Centriolar Plaque Architecture and Function Across Eukaryotic Diversity Using Expansion Microscopy and Proteomics is a NIGMS - National Institute of General Medical Sciences grant providing up to $396K for university, nonprofit, healthcare org. Applications are due 2031-02-28 (open). Check eligibility and apply with FindGrants.
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Eligibility
How to Apply
Up to $396K
2031-02-28
- 1Confirm your organization is eligible for Defining Centriolar Plaque Architecture and Function Across Eukaryotic Diversity Using Expansion Microscopy and Proteomics from NIGMS - National Institute of General Medical Sciences, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIGMS - National Institute of General Medical Sciences before the deadline.
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Defining Centriolar Plaque Architecture and Function Across Eukaryotic Diversity Using Expansion Microscopy and Proteomics: Frequently Asked Questions
Who is eligible for the Defining Centriolar Plaque Architecture and Function Across Eukaryotic Diversity Using Expansion Microscopy and Proteomics?
Defining Centriolar Plaque Architecture and Function Across Eukaryotic Diversity Using Expansion Microscopy and Proteomics is offered by NIGMS - National Institute of General Medical Sciences and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Defining Centriolar Plaque Architecture and Function Across Eukaryotic Diversity Using Expansion Microscopy and Proteomics provide?
Defining Centriolar Plaque Architecture and Function Across Eukaryotic Diversity Using Expansion Microscopy and Proteomics provides up to $396K per award from NIGMS - National Institute of General Medical Sciences. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Defining Centriolar Plaque Architecture and Function Across Eukaryotic Diversity Using Expansion Microscopy and Proteomics deadline?
Applications for Defining Centriolar Plaque Architecture and Function Across Eukaryotic Diversity Using Expansion Microscopy and Proteomics are due 2031-02-28 (open). Because deadlines can change, verify the date with the funder, NIGMS - National Institute of General Medical Sciences, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Defining Centriolar Plaque Architecture and Function Across Eukaryotic Diversity Using Expansion Microscopy and Proteomics?
To apply for Defining Centriolar Plaque Architecture and Function Across Eukaryotic Diversity Using Expansion Microscopy and Proteomics, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIGMS - National Institute of General Medical Sciences.