Coupling of protein synthesis with cell division
About This Grant
Cell growth and division are tightly linked processes, and protein synthesis plays a central role in regulating both. This research aims to uncover how cells coordinate protein synthesis with cell division. It exploits the experimental advantages of budding yeast to tackle this problem. Project 1 will answer how nutrients adjust the synthesis of Cak1. This enzyme phosphorylates and activates Cdk, the master regulator of cell division. The proposed experiments will define the translational control of CAK1 as a function of nutrient status. They will provide a mechanism that ties Cdk activation and cell division to growth conditions. Project 2 focuses on the translational control of CLN3. This mRNA encodes a G1 cyclin that turns Cdk on, committing cells to divide. Preliminary evidence points to a heightened ribosomal association of CLN3 early in the cell cycle. The proposed experiments will measure CLN3 mRNA localization and translation at the single-cell level. They will also identify RNA-binding proteins that interact with CLN3 using proximity labeling. Project 3 will elucidate the translational control of ADE17 in the cell cycle. Ade17 is a crucial enzyme of one-carbon metabolism and purine biosynthesis. Changes in Ade17 levels affect the size of cells and their commitment to divide. The proposed experiments will answer how translational control of ADE17 mRNA is linked to the purine flux needed for cell cycle progression. This project will provide significant insights into how protein synthesis and metabolic cues converge on the machinery for cell division. The results will have broad implications for controlling cell proliferation.
Grant Summary
Coupling of protein synthesis with cell division is a NIGMS - National Institute of General Medical Sciences grant providing up to $424K for university, nonprofit, healthcare org. Applications are due 2031-02-28 (open). Check eligibility and apply with FindGrants.
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How to Apply
Up to $424K
2031-02-28
- 1Confirm your organization is eligible for Coupling of protein synthesis with cell division from NIGMS - National Institute of General Medical Sciences, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIGMS - National Institute of General Medical Sciences before the deadline.
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Coupling of protein synthesis with cell division: Frequently Asked Questions
Who is eligible for the Coupling of protein synthesis with cell division?
Coupling of protein synthesis with cell division is offered by NIGMS - National Institute of General Medical Sciences and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Coupling of protein synthesis with cell division provide?
Coupling of protein synthesis with cell division provides up to $424K per award from NIGMS - National Institute of General Medical Sciences. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Coupling of protein synthesis with cell division deadline?
Applications for Coupling of protein synthesis with cell division are due 2031-02-28 (open). Because deadlines can change, verify the date with the funder, NIGMS - National Institute of General Medical Sciences, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Coupling of protein synthesis with cell division?
To apply for Coupling of protein synthesis with cell division, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIGMS - National Institute of General Medical Sciences.