High-energy human milk diets in the first two weeks after birth to reduce the severity of respiratory morbidity in extremely preterm infants
NHLBI - National Heart Lung and Blood Institute
About This Grant
PROJECT SUMMARY This hypothesis-driven, patient-oriented pilot randomized clinical trial will evaluate whether providing a high- energy human milk diet during the first two weeks after birth reduces respiratory morbidity in extremely preterm (EPT) infants. EPT infants, born at 28 weeks of gestation or earlier, have immature lungs and a high risk of developing bronchopulmonary dysplasia (BPD)—a chronic lung disease that increases mortality and long-term developmental complications. Early enteral nutrition is critical for lung development, yet most EPT infants receive insufficient energy during the first 14 days after birth. Docosahexaenoic acid (DHA) and arachidonic acid (ARA) supplementation is a promising strategy to increase energy intake through human milk, but there is no consensus on whether fat- enriched or protein-enriched diets are more beneficial for improving lung function. Building on findings from our recent NIH-funded trial, which demonstrated that protein-enriched diets improved growth and potentially reduced BPD severity, we will now assess whether a DHA/ARA-enriched exclusive human milk diet can achieve superior benefits. In this trial, we will randomize 150 EPT infants to receive either an exclusive human milk diet enriched with a commercially available DHA/ARA supplement or a standard, exclusive human milk diet during the first 14 days after birth. The primary outcome is the severity of respiratory morbidity at term equivalent age. We will also evaluate the feasibility of using non-invasive oscillometry to measure lung function in this population. This study will inform the design of a larger clinical trial and may establish that early enteral energy provision— unlike parenteral nutrition—provides measurable respiratory benefits. The findings could reshape neonatal nutrition strategies and optimize care for preterm infants at risk of BPD.
Grant Summary
High-energy human milk diets in the first two weeks after birth to reduce the severity of respiratory morbidity in extremely preterm infants is a NHLBI - National Heart Lung and Blood Institute grant providing up to $181K for university, nonprofit, healthcare org. Applications are due 2029-03-31 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $181K
2029-03-31
- 1Confirm your organization is eligible for High-energy human milk diets in the first two weeks after birth to reduce the severity of respiratory morbidity in extremely preterm infants from NHLBI - National Heart Lung and Blood Institute, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NHLBI - National Heart Lung and Blood Institute before the deadline.
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High-energy human milk diets in the first two weeks after birth to reduce the severity of respiratory morbidity in extremely preterm infants: Frequently Asked Questions
Who is eligible for the High-energy human milk diets in the first two weeks after birth to reduce the severity of respiratory morbidity in extremely preterm infants?
High-energy human milk diets in the first two weeks after birth to reduce the severity of respiratory morbidity in extremely preterm infants is offered by NHLBI - National Heart Lung and Blood Institute and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the High-energy human milk diets in the first two weeks after birth to reduce the severity of respiratory morbidity in extremely preterm infants provide?
High-energy human milk diets in the first two weeks after birth to reduce the severity of respiratory morbidity in extremely preterm infants provides up to $181K per award from NHLBI - National Heart Lung and Blood Institute. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the High-energy human milk diets in the first two weeks after birth to reduce the severity of respiratory morbidity in extremely preterm infants deadline?
Applications for High-energy human milk diets in the first two weeks after birth to reduce the severity of respiratory morbidity in extremely preterm infants are due 2029-03-31 (open). Because deadlines can change, verify the date with the funder, NHLBI - National Heart Lung and Blood Institute, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the High-energy human milk diets in the first two weeks after birth to reduce the severity of respiratory morbidity in extremely preterm infants?
To apply for High-energy human milk diets in the first two weeks after birth to reduce the severity of respiratory morbidity in extremely preterm infants, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NHLBI - National Heart Lung and Blood Institute.