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Improving PrEP engagement among hospitalized people who use substances: a pilot study

NIDA - National Institute on Drug Abuse

open
OpenLast verified: 2026-06-19

About This Grant

ABSTRACT People who use substances (PWUS) are an HIV priority population. Substance use is a major driver of HIV transmission, increasing risk of infection while decreasing adherence to prevention tools such as condoms or pre-exposure prophylaxis (PrEP). PWUS face multiple, intersecting barriers that limit access to and acceptability of PrEP, and thus PrEP uptake among PWUS remains alarmingly low. For many PWUS who do not regularly access care, acute hospitalizations represent “touchpoints” to engage them in treatment for substance use disorders and prevention of related risks such as HIV. Addiction consult services (ACS) – multidisciplinary clinical teams with expertise in addiction treatment – are effective at connecting PWUS to evidence-based addiction treatments and represent an obvious opportunity for engaging PWUS in PrEP. However, almost no studies have examined how ACS-driven PrEP could best be implemented to address the needs of both PWUS and the clinicians caring for them in the hospital. This application proposes formative research to identify key determinants of ACS-driven PrEP and to develop and preliminarily test a bundle of implementation strategies. Guided by the Consolidated Framework for Implementation Research, we will first identify key barriers and facilitators to ACS-driven PrEP through semi-structured interviews with twenty hospitalized PWUS and twenty future implementers of it (Aim 1). Using key tenets of Implementation Mapping, we will then lead a Taskforce of PWUS and key health system partners in developing a bundle of implementation strategies for ACS-driven PrEP with high potential for success (Aim 2). Finally, we will pilot test the bundle over 12 months to examine feasibility, acceptability, appropriateness, adoption, fidelity, and preliminary effectiveness (Aim 3). Findings from this study will inform the design of a subsequent R01 to fully test the effectiveness and implementation of ACS-driven PrEP. Ultimately, this work will advance our understanding of how to improve PrEP uptake and HIV transmission rates for PWUS.

Grant Summary

Improving PrEP engagement among hospitalized people who use substances: a pilot study is a NIDA - National Institute on Drug Abuse grant providing up to $756K for university, nonprofit, healthcare org. Applications are due 2029-02-28 (open). Check eligibility and apply with FindGrants.

Focus Areas

health research

Eligibility

universitynonprofithealthcare org

How to Apply

Funding Range

Up to $756K

Deadline

2029-02-28

Complexity
Medium
  1. 1Confirm your organization is eligible for Improving PrEP engagement among hospitalized people who use substances: a pilot study from NIDA - National Institute on Drug Abuse, checking organization type, location, and any population or project requirements.
  2. 2Gather the required documents and information, including your organization details, project plan, and budget figures.
  3. 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
  4. 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIDA - National Institute on Drug Abuse before the deadline.
This record is a past award, contract, or funder profile — useful for research, but not an open grant application. Check the original source for current opportunities from this funder.

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Improving PrEP engagement among hospitalized people who use substances: a pilot study: Frequently Asked Questions

Who is eligible for the Improving PrEP engagement among hospitalized people who use substances: a pilot study?

Improving PrEP engagement among hospitalized people who use substances: a pilot study is offered by NIDA - National Institute on Drug Abuse and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.

How much funding does the Improving PrEP engagement among hospitalized people who use substances: a pilot study provide?

Improving PrEP engagement among hospitalized people who use substances: a pilot study provides up to $756K per award from NIDA - National Institute on Drug Abuse. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.

When is the Improving PrEP engagement among hospitalized people who use substances: a pilot study deadline?

Applications for Improving PrEP engagement among hospitalized people who use substances: a pilot study are due 2029-02-28 (open). Because deadlines can change, verify the date with the funder, NIDA - National Institute on Drug Abuse, and give yourself enough time to prepare a complete, competitive application before the close date.

How do you apply for the Improving PrEP engagement among hospitalized people who use substances: a pilot study?

To apply for Improving PrEP engagement among hospitalized people who use substances: a pilot study, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIDA - National Institute on Drug Abuse.

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