Resolving Sleep Troubles in Childhood Leukemia (REST)
About This Grant
ABSTRACT Acute lymphoblastic leukemia (ALL) is the most common cancer diagnosed in childhood. Although risk-adapted therapy and supportive care have improved survival rates, children who receive chemotherapy continue to experience reduced quality of life, including poor sleep health and fatigue long after treatment. Poor sleep significantly elevates risk for deleterious physical and mental health problems in all children and exacerbates risks in ALL patients. While cognitive-behavioral therapy for pediatric insomnia (CBT-PI) is a ‘gold standard’ intervention, it is severely underutilized in pediatric cancer. Guided by conceptual models of sleep disturbance in pediatric cancer and an intervention mapping framework (IM-ADAPT), we propose to derive and test an adapted, telehealth-delivered CBT-PI protocol, REsolving Sleep Troubles in Childhood Leukemia (REST). The REST protocol will address the unique sleep challenges faced by all children receiving maintenance therapy and the ecologies impacting sleep health among heterogeneous families. To adapt CBT-PI, we will engage in iterative refinements, collaborate with an Expert Panel, gather insights from behavioral health providers, and test the usability of intervention materials. We will then evaluate the preliminary efficacy of REST in a pilot randomized controlled trial (n = 72) comparing REST to a sleep education control group. Participants will be children ages 5-10 years and their caregiver. In addition to feasibility and acceptability, primary outcomes including objective (actigraphy) and subjective (caregiver and child report) sleep patterns, daytime fatigue, and circadian rhythms (diurnal salivary cortisol) will be examined at three timepoints (pre-intervention, post-intervention, and 3-month follow up). We also plan to explore potential predictors of REST’s effects including child and parenting/family characteristics. We hypothesize REST will be feasible and acceptable, and produce greater improvements in sleep, fatigue and circadian rhythms than an education control condition. The proposed project addresses critical gaps in care for children with ALL and will directly inform a larger effectiveness trial.
Grant Summary
Resolving Sleep Troubles in Childhood Leukemia (REST) is a NCI - National Cancer Institute grant providing up to $321K for university, nonprofit, healthcare org. Applications are due 2029-06-30 (open). Check eligibility and apply with FindGrants.
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How to Apply
Up to $321K
2029-06-30
- 1Confirm your organization is eligible for Resolving Sleep Troubles in Childhood Leukemia (REST) from NCI - National Cancer Institute, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NCI - National Cancer Institute before the deadline.
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Resolving Sleep Troubles in Childhood Leukemia (REST): Frequently Asked Questions
Who is eligible for the Resolving Sleep Troubles in Childhood Leukemia (REST)?
Resolving Sleep Troubles in Childhood Leukemia (REST) is offered by NCI - National Cancer Institute and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Resolving Sleep Troubles in Childhood Leukemia (REST) provide?
Resolving Sleep Troubles in Childhood Leukemia (REST) provides up to $321K per award from NCI - National Cancer Institute. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Resolving Sleep Troubles in Childhood Leukemia (REST) deadline?
Applications for Resolving Sleep Troubles in Childhood Leukemia (REST) are due 2029-06-30 (open). Because deadlines can change, verify the date with the funder, NCI - National Cancer Institute, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Resolving Sleep Troubles in Childhood Leukemia (REST)?
To apply for Resolving Sleep Troubles in Childhood Leukemia (REST), confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NCI - National Cancer Institute.