PEth-based contingency management for alcohol use disorder in patient with alcohol-associated liver disease
About This Grant
Abstract: Alcohol-Associated Liver Disease (ALD) is a major public health problem, accounting for nearly half of all liver-related deaths in the United States. Despite the clear benefits of alcohol abstinence, achieving and maintaining abstinence remains a significant challenge for many ALD patients. Contingency Management (CM), an evidence-based behavioral intervention that provides tangible rewards for positive behavior change, has shown promise in promoting abstinence in alcohol use disorders. However, the application of CM in ALD patients has been limited, partly due to challenges in monitoring alcohol use over extended periods. This study proposes a novel approach that integrates CM with phosphatidylethanol (PEth) testing, an innovative alcohol biomarker with a longer detection window, to promote alcohol abstinence in ALD patients in the hepatology clinic. The specific aims are: 1) to establish the feasibility and acceptability of PEth-based CM for alcohol use in the hepatology clinic for ALD patients; 2) to evaluate the preliminary efficacy of a PEth-based CM intervention in achieving alcohol abstinence; and 3) to explore sociodemographic and clinical factors that are associated with treatment response (alcohol abstinence and alcohol reduction). The study will conduct a pilot randomized controlled trial (REINFORCE Trial) to compare the effectiveness of a 12-week PEth-based CM intervention against a control group receiving treatment as usual in a cohort of ALD patients with alcohol use in the hepatology clinic. The primary outcome will be alcohol abstinence, with secondary outcomes including alcohol reduction, treatment engagement, liver disease severity, and health-related quality of life. Exploratory analyses will examine potential moderators of treatment response. This innovative study addresses a critical gap in the treatment of alcohol use in ALD patients and has the potential to significantly advance scientific knowledge, improve clinical practice, and reduce the public health burden of alcohol-related liver disease. The findings will inform the development of personalized treatment approaches and guide the design of future large-scale clinical trials.
Grant Summary
PEth-based contingency management for alcohol use disorder in patient with alcohol-associated liver disease is a NIAAA - National Institute on Alcohol Abuse and Alcoholism grant providing up to $226K for university, nonprofit, healthcare org. Applications are due 2029-04-30 (open). Check eligibility and apply with FindGrants.
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Focus Areas
Eligibility
How to Apply
Up to $226K
2029-04-30
- 1Confirm your organization is eligible for PEth-based contingency management for alcohol use disorder in patient with alcohol-associated liver disease from NIAAA - National Institute on Alcohol Abuse and Alcoholism, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIAAA - National Institute on Alcohol Abuse and Alcoholism before the deadline.
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PEth-based contingency management for alcohol use disorder in patient with alcohol-associated liver disease: Frequently Asked Questions
Who is eligible for the PEth-based contingency management for alcohol use disorder in patient with alcohol-associated liver disease?
PEth-based contingency management for alcohol use disorder in patient with alcohol-associated liver disease is offered by NIAAA - National Institute on Alcohol Abuse and Alcoholism and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the PEth-based contingency management for alcohol use disorder in patient with alcohol-associated liver disease provide?
PEth-based contingency management for alcohol use disorder in patient with alcohol-associated liver disease provides up to $226K per award from NIAAA - National Institute on Alcohol Abuse and Alcoholism. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the PEth-based contingency management for alcohol use disorder in patient with alcohol-associated liver disease deadline?
Applications for PEth-based contingency management for alcohol use disorder in patient with alcohol-associated liver disease are due 2029-04-30 (open). Because deadlines can change, verify the date with the funder, NIAAA - National Institute on Alcohol Abuse and Alcoholism, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the PEth-based contingency management for alcohol use disorder in patient with alcohol-associated liver disease?
To apply for PEth-based contingency management for alcohol use disorder in patient with alcohol-associated liver disease, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIAAA - National Institute on Alcohol Abuse and Alcoholism.