Training Institute for the Implementation of GEnomics Research (TIGER)

About This Grant

PROJECT SUMMARY Background: Compared to the rapid pace of genomic discoveries, the adoption of genomics-informed health applications lags. According to the NHGRI’s Strategic Vision for 2030, there is a critical need for implementation science approaches to bridge the gap between discovery and real-world application. Our recent NIH portfolio analysis and systematic review found that less than 2% of genomics grants and peer-reviewed publications integrate implementation science frameworks. To fully leverage genomic advancements, a workforce trained in applying implementation science to genomics-informed health applications is essential. Goal: The Training Institute for the Implementation of GEnomics Research (TIGER) aims to increase the implementation science capacity for genomics by training investigators across the US. The program will prepare investigators to effectively implement genomics research in real-world settings, ensuring widespread availability of genomics-informed health applications, with an emphasis on populations with limited resources. Approach: Aim 1: Expand and implement TIGER to train a cohort of 32 fellows annually (160 over the five-year grant period). TIGER is a hybrid program combining virtual lectures with an in-person workshop. It is targeted at postdoctoral associates and research faculty applying genomics in the prevention and treatment of disease. Fellows will be paired with mentors to build competencies in implementation science tailored to their research. We will work with the established Genomic Data Science Community Network to recruit a high-quality pool of fellows with a broad range of skills, perspectives, and backgrounds. Aim 2: Continuously evaluate and improve the TIGER program. A robust evaluation plan, guided by a logic model, will track data from fellows, including surveys, assessments, and program metrics, to refine the curriculum and mentorship process. Aim 3: Disseminate TIGER nationally to build a network of genomics implementation science champions. Course materials will be made publicly accessible, and findings will be shared via conferences, publications, and social media. TIGER alumni will be provided with networking opportunities to foster ongoing engagement, and they will be equipped with tools to disseminate TIGER knowledge. Innovation and Impact: TIGER is a pioneering educational initiative designed to address the cross-cutting need for advanced training in the application of implementation science to genomics. This program is significant because it will promote the incorporation of implementation science methods to adopt genomics in real world settings where evidence-based interventions exist but are not commonly applied. We will offer this training using innovative methods for engaging adult learners to build pragmatic skills that can be applied to a range of clinical research and quality improvement programs at learners’ home institutions. Our approach to training delivery is accessible (hybrid design), rigorous, and allows for continuous refinement and improvement through a robust evaluation plan.