Identification of axon length-dependent gene expression programs
NINDS - National Institute of Neurological Disorders and Stroke
About This Grant
PROJECT SUMMARY Many neurodegenerative disorders (NDDs) preferentially affect neurons with long or complex axonal arbors. However, our understanding of this specific vulnerability is limited. We hypothesize that axon length represents a molecularly definable source of vulnerability common to many NDDs, and indeed we found that Drosophila neurons with long axons are intrinsically more vulnerable to degeneration than same-type neurons with short axons. In preliminary studies we have defined molecular markers whose expression covaries with axon length and have developed a robust platform for single cell transcriptomics, in vivo analysis of axon length-dependent effects on synaptic connectivity, and behavioral diagnostics of length-dependent axon degeneration. We will leverage the significant advantages of this system to systematically identify genes whose levels covary with axon length and assay functions for these genes in length-dependent axon degeneration. Altogether, our studies will provide fundamental insight into mechanisms of axon length-dependency in degeneration, addressing a fundamental gap in our understanding of NDDs.
Grant Summary
Identification of axon length-dependent gene expression programs is a NINDS - National Institute of Neurological Disorders and Stroke grant providing up to $428K for university, nonprofit, healthcare org. Applications are due 2028-04-30 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $428K
2028-04-30
- 1Confirm your organization is eligible for Identification of axon length-dependent gene expression programs from NINDS - National Institute of Neurological Disorders and Stroke, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NINDS - National Institute of Neurological Disorders and Stroke before the deadline.
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Identification of axon length-dependent gene expression programs: Frequently Asked Questions
Who is eligible for the Identification of axon length-dependent gene expression programs?
Identification of axon length-dependent gene expression programs is offered by NINDS - National Institute of Neurological Disorders and Stroke and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Identification of axon length-dependent gene expression programs provide?
Identification of axon length-dependent gene expression programs provides up to $428K per award from NINDS - National Institute of Neurological Disorders and Stroke. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Identification of axon length-dependent gene expression programs deadline?
Applications for Identification of axon length-dependent gene expression programs are due 2028-04-30 (open). Because deadlines can change, verify the date with the funder, NINDS - National Institute of Neurological Disorders and Stroke, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Identification of axon length-dependent gene expression programs?
To apply for Identification of axon length-dependent gene expression programs, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NINDS - National Institute of Neurological Disorders and Stroke.