Early Detection of Respiratory Impairments in ALS: A Novel Diagnostic Approach
NINDS - National Institute of Neurological Disorders and Stroke
About This Grant
ABSTRACT Title: Early Detection of Respiratory Impairments in ALS: A Novel Diagnostic Approach Early detection of respiratory impairments in amyotrophic lateral sclerosis (ALS) is crucial for improving survival and quality of life. Current clinical tests, focusing on volitional forced breathing, fail to adequately challenge the respiratory neural drive, leading to undetected and therefore unmitigated loss of respiratory function in the early phases of the disease. Unlike limb muscles, respiratory muscles are controlled by both involuntary (ponto-medullary-spinal) and voluntary (cortico-spinal) pathways. This study proposes a novel diagnostic test to detect automatic breathing impairments in ALS, combining airway occlusion pressure (P0.1) and Chemosensitivity (Δ minute ventilation per Δ%SpO2). Preliminary data from asymptomatic genetic ALS carriers indicate deficits in automatic breathing, despite normal functional vital capacity (FVC) and maximum inspiratory pressure (MIP). We hypothesize that a composite score of P0.1 and Chemosensitivity can identify early respiratory impairments in ALS. The study aims to develop a linear prediction risk score and ROC cutoff to distinguish healthy controls from symptomatic ALS patients, and to identify subclinical impairments in asymptomatic/pre-symptomatic carriers. Microstructural changes in the brainstem-spinal cord and elevated blood neurofilament light chain (Nf-L) levels will be assessed to confirm the diagnostic test’s effectiveness. This innovative approach aims to fill a critical gap in ALS care by enabling earlier intervention and providing crucial markers for future clinical trials.
Grant Summary
Early Detection of Respiratory Impairments in ALS: A Novel Diagnostic Approach is a NINDS - National Institute of Neurological Disorders and Stroke grant providing up to $196K for university, nonprofit, healthcare org. Applications are due 2028-03-31 (open). Check eligibility and apply with FindGrants.
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Up to $196K
2028-03-31
- 1Confirm your organization is eligible for Early Detection of Respiratory Impairments in ALS: A Novel Diagnostic Approach from NINDS - National Institute of Neurological Disorders and Stroke, checking organization type, location, and any population or project requirements.
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Early Detection of Respiratory Impairments in ALS: A Novel Diagnostic Approach: Frequently Asked Questions
Who is eligible for the Early Detection of Respiratory Impairments in ALS: A Novel Diagnostic Approach?
Early Detection of Respiratory Impairments in ALS: A Novel Diagnostic Approach is offered by NINDS - National Institute of Neurological Disorders and Stroke and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Early Detection of Respiratory Impairments in ALS: A Novel Diagnostic Approach provide?
Early Detection of Respiratory Impairments in ALS: A Novel Diagnostic Approach provides up to $196K per award from NINDS - National Institute of Neurological Disorders and Stroke. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Early Detection of Respiratory Impairments in ALS: A Novel Diagnostic Approach deadline?
Applications for Early Detection of Respiratory Impairments in ALS: A Novel Diagnostic Approach are due 2028-03-31 (open). Because deadlines can change, verify the date with the funder, NINDS - National Institute of Neurological Disorders and Stroke, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Early Detection of Respiratory Impairments in ALS: A Novel Diagnostic Approach?
To apply for Early Detection of Respiratory Impairments in ALS: A Novel Diagnostic Approach, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NINDS - National Institute of Neurological Disorders and Stroke.