Mechanistic Dissection of SRRM2-Mediated RNA Splicing and Subnuclear RNA Organization in Human Neurons
About This Grant
PROJECT SUMMARY Schizophrenia is a severe neuropsychiatric disorder with high heritability, yet the molecular mechanisms linking genetic risk to neuronal dysfunction remain poorly understood. Emerging evidence points to post- transcriptional RNA regulation, such as RNA-binding proteins like Serine/Arginine Repetitive Matrix protein 2 (SRRM2), as a critical contributor to the disease. SRRM2 is a nuclear speckle-associated splicing regulator that has been implicated in schizophrenia risk through both common and rare variant studies. However, its functional role in human neurons remains largely unexplored. This project has two main aims. The first aim is to develop a novel spatial transcriptomics platform, Spatial RNA–Protein Interactome MERFISH (SPRIM), to visualize endogenous RNA–protein interactions at subcellular resolution. SPRIM integrates antibody-guided localization, in situ tagmentation, and multiplexed RNA detection to map RNA-binding protein targets in intact cells. The second aim is to investigate the roles of SRRM2 in engineered human induced neurons. Using adeno associated based gene editing, spatial imaging, and electrophysiology, we will assess how SRRM2 heterozygous loss affects RNA splicing, transcript localization, and neuronal electrophysiological properties. This exploratory project is well aligned with the NIH R21 funding mechanism, which supports innovative research. By developing a novel spatial omic platform and applying it to dissect SRRM2 function in genetically engineered human neurons, we aim to uncover foundational principles of RNA-binding protein mediated RNA regulation in brain development and psychiatric disease.
Grant Summary
Mechanistic Dissection of SRRM2-Mediated RNA Splicing and Subnuclear RNA Organization in Human Neurons is a NIMH - National Institute of Mental Health grant providing up to $462K for university, nonprofit, healthcare org. Applications are due 2028-08-13 (open). Check eligibility and apply with FindGrants.
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How to Apply
Up to $462K
2028-08-13
- 1Confirm your organization is eligible for Mechanistic Dissection of SRRM2-Mediated RNA Splicing and Subnuclear RNA Organization in Human Neurons from NIMH - National Institute of Mental Health, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIMH - National Institute of Mental Health before the deadline.
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Mechanistic Dissection of SRRM2-Mediated RNA Splicing and Subnuclear RNA Organization in Human Neurons: Frequently Asked Questions
Who is eligible for the Mechanistic Dissection of SRRM2-Mediated RNA Splicing and Subnuclear RNA Organization in Human Neurons?
Mechanistic Dissection of SRRM2-Mediated RNA Splicing and Subnuclear RNA Organization in Human Neurons is offered by NIMH - National Institute of Mental Health and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Mechanistic Dissection of SRRM2-Mediated RNA Splicing and Subnuclear RNA Organization in Human Neurons provide?
Mechanistic Dissection of SRRM2-Mediated RNA Splicing and Subnuclear RNA Organization in Human Neurons provides up to $462K per award from NIMH - National Institute of Mental Health. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Mechanistic Dissection of SRRM2-Mediated RNA Splicing and Subnuclear RNA Organization in Human Neurons deadline?
Applications for Mechanistic Dissection of SRRM2-Mediated RNA Splicing and Subnuclear RNA Organization in Human Neurons are due 2028-08-13 (open). Because deadlines can change, verify the date with the funder, NIMH - National Institute of Mental Health, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Mechanistic Dissection of SRRM2-Mediated RNA Splicing and Subnuclear RNA Organization in Human Neurons?
To apply for Mechanistic Dissection of SRRM2-Mediated RNA Splicing and Subnuclear RNA Organization in Human Neurons, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIMH - National Institute of Mental Health.