Synaptic plasticity and signaling in 22q11.2 deletion syndrome model mice
About This Grant
Abstract 22q11.2 deletion syndrome (22q11.2DS) is the most common chromosomal microdeletion in humans, with an incidence of ~1/4000 live births. Symptoms associated with 22q11.2DS are broad and unpredictable, ranging from cardiac defects to cognitive deficits and increased risk of schizophrenia. 22q11.2DS patients commonly experience learning delays and deficits in working memory, which have lifelong quality of life impacts. Notably, using a recently developed full deletion mouse model of 22q11.2DS, our lab has discovered dramatic deficits in synaptic structural plasticity in the hippocampal CA1 region. Our central hypothesis is that the learning and memory deficits of 22q11.2DS 22q patients are due to profound alterations to glutamatergic synaptic plasticity and signaling in the hippocampus. To test this hypothesis, we will investigate the synaptic signaling mechanisms (Aim 1) and single-cell gene expression profiles (Aim 2) underlying disruptions in plasticity of hippocampal CA1 neurons in 22q11.2DS model mice. Genome-wide sequencing suggests 22q11.2DS presents a threshold lowering effect for schizophrenia, and that the 22q deletion creates a vulnerable substrate for the manifestation of other schizophrenia risk factors. Perturbations in pathways that support synaptic structural plasticity likely contribute to this increased vulnerability to schizophrenia in 22q11.2DS patients. The proposed experiments will fill a gap in knowledge concerning the molecular and cellular mechanisms responsible for deficits in place memory and working memory associated with 22q11.2DS. Knowledge of these signaling pathways move us closer to developing therapeutics to manage the cognitive effects of this unpredictable and impactful disease.
Grant Summary
Synaptic plasticity and signaling in 22q11.2 deletion syndrome model mice is a NIMH - National Institute of Mental Health grant providing up to $443K for university, nonprofit, healthcare org. Applications are due 2028-06-30 (open). Check eligibility and apply with FindGrants.
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Up to $443K
2028-06-30
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Synaptic plasticity and signaling in 22q11.2 deletion syndrome model mice: Frequently Asked Questions
Who is eligible for the Synaptic plasticity and signaling in 22q11.2 deletion syndrome model mice?
Synaptic plasticity and signaling in 22q11.2 deletion syndrome model mice is offered by NIMH - National Institute of Mental Health and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Synaptic plasticity and signaling in 22q11.2 deletion syndrome model mice provide?
Synaptic plasticity and signaling in 22q11.2 deletion syndrome model mice provides up to $443K per award from NIMH - National Institute of Mental Health. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Synaptic plasticity and signaling in 22q11.2 deletion syndrome model mice deadline?
Applications for Synaptic plasticity and signaling in 22q11.2 deletion syndrome model mice are due 2028-06-30 (open). Because deadlines can change, verify the date with the funder, NIMH - National Institute of Mental Health, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Synaptic plasticity and signaling in 22q11.2 deletion syndrome model mice?
To apply for Synaptic plasticity and signaling in 22q11.2 deletion syndrome model mice, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIMH - National Institute of Mental Health.