Puberty and Interoceptive Networks in Anxiety
About This Grant
PROJECT ABSTRACT Adolescence is associated with worsening anxiety, but the biological mechanism for this phenomenon is not understood. Much work has focused on how changes to social and cognitive processing during adolescence might contribute to anxiety symptoms. Very little work has investigated how pubertal changes to the body itself may contribute to worsening anxiety symptoms. Specifically, puberty is known to impact representation of the body in cortex. This in turn may impact the ability to identify and interpret interoceptive signals in a bottom-up manner, thereby exacerbating anxiety symptoms in vulnerable adolescents. Identification of novel neural targets and mechanisms associated with anxiety during adolescence can lead to interventions that reduce illness burden in adolescence and adulthood. Primary somatosensory (S1) and insular cortices are two potential neural substrates that are associated with cortical representation of the body, as well as interoceptive function. Both S1 and insular cortices show structural and functional shifts during puberty and are associated with anxiety symptoms in adults. The function of these regions during puberty and their relationship to anxiety symptoms has not been characterized. This functional magnetic resonance imaging (fMRI) study seeks to understand the neurofunctional correlates of body representation and interoceptive function and their relationship to anxiety symptoms during puberty. In this cross-sectional study, youth ages 11-15 (n=75) will complete assessments and self-reports of anxiety symptoms and pubertal development, as well as a magnetic resonance imagining (MRI) scan session. The MRI session will include an emotional cardiac interoceptive functional MRI task and a resting state scan. Participants will also complete an electrocardiogram task designed to assess interoceptive function, as well as a behavioral task designed to assess body representation, both outside of the scanner. We aim to understand the neural correlates of body representation during puberty and the relationship between interoceptive function/its neural substrates and physical symptoms of anxiety in adolescents. We also will explore the stability of these constructs over time and the predictive utility of the function of somatosensory and insular cortices for understanding anxiety symptoms. This study has the potential to identify novel targets for early intervention that could prevent or mitigate anxiety disorders in adolescence and adulthood.
Grant Summary
Puberty and Interoceptive Networks in Anxiety is a NIMH - National Institute of Mental Health grant providing up to $475K for university, nonprofit, healthcare org. Applications are due 2028-07-31 (open). Check eligibility and apply with FindGrants.
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How to Apply
Up to $475K
2028-07-31
- 1Confirm your organization is eligible for Puberty and Interoceptive Networks in Anxiety from NIMH - National Institute of Mental Health, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIMH - National Institute of Mental Health before the deadline.
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Puberty and Interoceptive Networks in Anxiety: Frequently Asked Questions
Who is eligible for the Puberty and Interoceptive Networks in Anxiety?
Puberty and Interoceptive Networks in Anxiety is offered by NIMH - National Institute of Mental Health and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Puberty and Interoceptive Networks in Anxiety provide?
Puberty and Interoceptive Networks in Anxiety provides up to $475K per award from NIMH - National Institute of Mental Health. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Puberty and Interoceptive Networks in Anxiety deadline?
Applications for Puberty and Interoceptive Networks in Anxiety are due 2028-07-31 (open). Because deadlines can change, verify the date with the funder, NIMH - National Institute of Mental Health, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Puberty and Interoceptive Networks in Anxiety?
To apply for Puberty and Interoceptive Networks in Anxiety, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIMH - National Institute of Mental Health.