Molecular Cellular and Circuit Level Mechanisms of Working Memory Maintenance
About This Grant
PROJECT SUMMARY Working memory allows past events to be transiently maintained in the brain so that it can be compared with ongoing experiences to drive behavior. This cognitive process has been shown to be severely impacted by the progression of many neuropsychiatric diseases and disorders. Thus, it is critical to understand the components of working memory to determine how normal mental function can be restored. Working memory must be selective to relevant stimuli and resistant to noise or irrelevant stimuli. It has been proposed that information is maintained through persistent activity at the single-cell or population level, either among local recurrently connected neurons or through long-range loops across multiple brain areas. Alternatively, it has been proposed that information could be maintained through activity-silent intracellular processes which are defined by specific genes and molecules. These theories are not necessarily mutually exclusive and may both be implemented in the nervous system. To achieve a comprehensive understanding of these mechanisms, it is necessary to investigate working memory across multiple biological scales spanning genes, cell types, local circuit dynamics, brain-wide communication, and behavior. Using a combination of multi-area two-photon calcium imaging, long-range anatomical tracing, cell-resolution optogenetic manipulation, and comprehensive spatial transcriptomic analysis, we will dissect working memory circuits as animals perform sensory-guided working memory tasks. In Aim 1, we will determine how specific stimuli are maintained in working memory by monitoring and perturbing local and long-range cortical activity to distinguish working memory maintenance from sensory-to-working-memory transformations. In Aim 2, we will determine the cellular and molecular mechanisms supporting local working memory by combining functional connectivity and gene expression measurements to distinguish their contributions to persistent activity and activity silent properties. Through this, we will determine the precise local and long-range dynamics that underlie working memory and the cellular and molecular properties that support these computations.
Grant Summary
Molecular Cellular and Circuit Level Mechanisms of Working Memory Maintenance is a NIMH - National Institute of Mental Health grant providing up to $450K for university, nonprofit, healthcare org. Applications are due 2028-03-14 (open). Check eligibility and apply with FindGrants.
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How to Apply
Up to $450K
2028-03-14
- 1Confirm your organization is eligible for Molecular Cellular and Circuit Level Mechanisms of Working Memory Maintenance from NIMH - National Institute of Mental Health, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIMH - National Institute of Mental Health before the deadline.
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Molecular Cellular and Circuit Level Mechanisms of Working Memory Maintenance: Frequently Asked Questions
Who is eligible for the Molecular Cellular and Circuit Level Mechanisms of Working Memory Maintenance?
Molecular Cellular and Circuit Level Mechanisms of Working Memory Maintenance is offered by NIMH - National Institute of Mental Health and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Molecular Cellular and Circuit Level Mechanisms of Working Memory Maintenance provide?
Molecular Cellular and Circuit Level Mechanisms of Working Memory Maintenance provides up to $450K per award from NIMH - National Institute of Mental Health. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Molecular Cellular and Circuit Level Mechanisms of Working Memory Maintenance deadline?
Applications for Molecular Cellular and Circuit Level Mechanisms of Working Memory Maintenance are due 2028-03-14 (open). Because deadlines can change, verify the date with the funder, NIMH - National Institute of Mental Health, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Molecular Cellular and Circuit Level Mechanisms of Working Memory Maintenance?
To apply for Molecular Cellular and Circuit Level Mechanisms of Working Memory Maintenance, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIMH - National Institute of Mental Health.