Isoform-Specific LEF1 Function in Hypothalamic Neurogenesis and Behavior
About This Grant
Project Summary Dysfunction of the Wnt signaling pathway has been associated with mental ilness, but the underlying molecular and cellular mechanisms remain elusive. Our laboratory has discovered an evolutionarily conserved role for the Wnt transcriptional effector Lef1 in generating hypothalamic neurons and innate behaviors linked to stress. LEF1 variants could thus contribute to human stress-related mood disorders, and we propose that the distinct expression and function of two highly conserved protein isoforms could provide a way to separate this role from the other essential roles of Lef1 in development. We will use zebrafish to test the hypothesis that isoform- specific control of Lef1-dependent transcription regulates hypothalamic neurogenesis and stress- related behavior. In Aim 1 we will determine how the Lef1 N-tail and B-tail isoforms affect protein function, and in Aim 2 we will determine whether each isoform is specifically required for neurogenesis and behavior. Our goal is to establish an evolutionarily conserved model that we can eventually translate to human mental health.
Grant Summary
Isoform-Specific LEF1 Function in Hypothalamic Neurogenesis and Behavior is a NIMH - National Institute of Mental Health grant providing up to $424K for university, nonprofit, healthcare org. Applications are due 2028-04-30 (open). Check eligibility and apply with FindGrants.
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Eligibility
How to Apply
Up to $424K
2028-04-30
- 1Confirm your organization is eligible for Isoform-Specific LEF1 Function in Hypothalamic Neurogenesis and Behavior from NIMH - National Institute of Mental Health, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIMH - National Institute of Mental Health before the deadline.
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Isoform-Specific LEF1 Function in Hypothalamic Neurogenesis and Behavior: Frequently Asked Questions
Who is eligible for the Isoform-Specific LEF1 Function in Hypothalamic Neurogenesis and Behavior?
Isoform-Specific LEF1 Function in Hypothalamic Neurogenesis and Behavior is offered by NIMH - National Institute of Mental Health and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Isoform-Specific LEF1 Function in Hypothalamic Neurogenesis and Behavior provide?
Isoform-Specific LEF1 Function in Hypothalamic Neurogenesis and Behavior provides up to $424K per award from NIMH - National Institute of Mental Health. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Isoform-Specific LEF1 Function in Hypothalamic Neurogenesis and Behavior deadline?
Applications for Isoform-Specific LEF1 Function in Hypothalamic Neurogenesis and Behavior are due 2028-04-30 (open). Because deadlines can change, verify the date with the funder, NIMH - National Institute of Mental Health, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Isoform-Specific LEF1 Function in Hypothalamic Neurogenesis and Behavior?
To apply for Isoform-Specific LEF1 Function in Hypothalamic Neurogenesis and Behavior, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIMH - National Institute of Mental Health.