Novel Statistical Models for Visual Field Progression in the Ocular Hypertension Treatment Study
NEI - National Eye Institute
About This Grant
Glaucoma is a leading cause of blindness, with primary open-angle glaucoma (POAG) affecting over three million Americans. The Ocular Hypertension Treatment Study (OHTS) provides a unique, high-quality longitudinal dataset to investigate visual field (VF) progression and improve early detection of POAG-related deterioration. Current diagnostic methods often fail to identify early-stage disease transitions, leading to delays in treatment and missed opportunities for intervention. Additionally, conventional metrics such as mean deviation (MD) overlook localized changes critical for assessing VF loss progression. This project aims to develop and implement novel statistical methodologies to enhance the detection and characterization of POAG progression. Specifically, we propose: (1) a change-point model for MD progression that integrates longitudinal MD measures with the time to detectable change, addressing variability in VF deterioration and identifying early disease transitions; (2) spatial-temporal modeling of pointwise VF progression to improve sensitivity in detecting localized changes, accounting for spatial correlations across retinal locations; and (3) development of a user-friendly R package to disseminate these methodologies for use by researchers and clinicians. By leveraging advanced statistical models and the extensive OHTS dataset, this research will refine estimates of differential progression rates, facilitate early identification of high-risk individuals, and optimize treatment strategies. Beyond glaucoma, these methods will have broad applicability in analyzing spatial-temporal data in other medical domains.
Grant Summary
Novel Statistical Models for Visual Field Progression in the Ocular Hypertension Treatment Study is a NEI - National Eye Institute grant providing up to $428K for university, nonprofit, healthcare org. Applications are due 2028-03-31 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $428K
2028-03-31
- 1Confirm your organization is eligible for Novel Statistical Models for Visual Field Progression in the Ocular Hypertension Treatment Study from NEI - National Eye Institute, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NEI - National Eye Institute before the deadline.
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Novel Statistical Models for Visual Field Progression in the Ocular Hypertension Treatment Study: Frequently Asked Questions
Who is eligible for the Novel Statistical Models for Visual Field Progression in the Ocular Hypertension Treatment Study?
Novel Statistical Models for Visual Field Progression in the Ocular Hypertension Treatment Study is offered by NEI - National Eye Institute and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Novel Statistical Models for Visual Field Progression in the Ocular Hypertension Treatment Study provide?
Novel Statistical Models for Visual Field Progression in the Ocular Hypertension Treatment Study provides up to $428K per award from NEI - National Eye Institute. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Novel Statistical Models for Visual Field Progression in the Ocular Hypertension Treatment Study deadline?
Applications for Novel Statistical Models for Visual Field Progression in the Ocular Hypertension Treatment Study are due 2028-03-31 (open). Because deadlines can change, verify the date with the funder, NEI - National Eye Institute, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Novel Statistical Models for Visual Field Progression in the Ocular Hypertension Treatment Study?
To apply for Novel Statistical Models for Visual Field Progression in the Ocular Hypertension Treatment Study, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NEI - National Eye Institute.