Multi-Modal, Multi-Depth, High Resolution Micro-Endoscope (M3D-HRME) for early cancer diagnostics
NIBIB - National Institute of Biomedical Imaging and Bioengineering
About This Grant
Multi-Modal, Multi-Depth, High Resolution Micro-Endoscope (M3D-HRME) for early cancer diagnostics Work pursued within this proposal will carry out feasibility studies to develop a new class of optical micro-endoscopic devices for early stage, cancer detection. The proposed solution will combine advances in state-of the art fabrication technologies to manufacture integrated miniature multi-lens objectives that will be combined with High Resolution Micro-Endoscope (HRME) for an efficient Multi-Modal, Multi-Depth cancer diagnostic imaging (called M3D- HRME). A set of mini-objectives will be integrated along the waveguide structures (fabricated in same process) imaging system, and enabled by 2-Photon Polymerization based additive manufacturing. The multi-lens unit will be printed directly on the top of the polished imaging fiber bundles. Its outer form will conform to the fiber bundle dimensions. The mini objectives included in the unit will provide different resolutions and/or imaging depths. The probe will be capable of front imaging as well as side viewing –internal wall of luminal structures like the cervical os for example. M3D-HRME will be used by moving it in contact across the tissue and real time mosaicked to provide complementary imaging sets – morphology (outer tissue layer) and microvasculature (70-140 microns below the top tissue layer). Note that there is clinical evidence that angiogenesis patterns change with dysplasia along with the changes in nuclear morphology. To accomplish project goals we will develop prototypes of multi-unit refractive rod-like objectives. M3D-HRME will provide 2-micron resolution (fluorescence - morphology) working along objective pairs to image 70-140 microns depths with 15-20 microns resolution (in dark field mode - microvasculature). The refractive changes to produce the multi-lens objectives will be obtained by modulating the laser power during 2-photon polymerization. In addition we will test system imaging metrics using in target and tissue imaging experiments. For example, we will evaluate imaging performance in normal volunteers imaging epithelial layer in oral cavity as well as in-vitro cervical tissue samples. Both front and side view imaging will be performed to assess system in both modes for future cervical cancer applications.
Grant Summary
Multi-Modal, Multi-Depth, High Resolution Micro-Endoscope (M3D-HRME) for early cancer diagnostics is a NIBIB - National Institute of Biomedical Imaging and Bioengineering grant providing up to $183K for university, nonprofit, healthcare org. Applications are due 2028-07-31 (open). Check eligibility and apply with FindGrants.
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Focus Areas
Eligibility
How to Apply
Up to $183K
2028-07-31
- 1Confirm your organization is eligible for Multi-Modal, Multi-Depth, High Resolution Micro-Endoscope (M3D-HRME) for early cancer diagnostics from NIBIB - National Institute of Biomedical Imaging and Bioengineering, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIBIB - National Institute of Biomedical Imaging and Bioengineering before the deadline.
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Multi-Modal, Multi-Depth, High Resolution Micro-Endoscope (M3D-HRME) for early cancer diagnostics: Frequently Asked Questions
Who is eligible for the Multi-Modal, Multi-Depth, High Resolution Micro-Endoscope (M3D-HRME) for early cancer diagnostics?
Multi-Modal, Multi-Depth, High Resolution Micro-Endoscope (M3D-HRME) for early cancer diagnostics is offered by NIBIB - National Institute of Biomedical Imaging and Bioengineering and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Multi-Modal, Multi-Depth, High Resolution Micro-Endoscope (M3D-HRME) for early cancer diagnostics provide?
Multi-Modal, Multi-Depth, High Resolution Micro-Endoscope (M3D-HRME) for early cancer diagnostics provides up to $183K per award from NIBIB - National Institute of Biomedical Imaging and Bioengineering. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Multi-Modal, Multi-Depth, High Resolution Micro-Endoscope (M3D-HRME) for early cancer diagnostics deadline?
Applications for Multi-Modal, Multi-Depth, High Resolution Micro-Endoscope (M3D-HRME) for early cancer diagnostics are due 2028-07-31 (open). Because deadlines can change, verify the date with the funder, NIBIB - National Institute of Biomedical Imaging and Bioengineering, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Multi-Modal, Multi-Depth, High Resolution Micro-Endoscope (M3D-HRME) for early cancer diagnostics?
To apply for Multi-Modal, Multi-Depth, High Resolution Micro-Endoscope (M3D-HRME) for early cancer diagnostics, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIBIB - National Institute of Biomedical Imaging and Bioengineering.