Leveraging targeted cell therapy to promote heart transplant tolerance through topical application of a nanoparticle infused polymeric membrane
NIBIB - National Institute of Biomedical Imaging and Bioengineering
About This Grant
Project Summary/Abstract According to the organ procurement and transplantation network, every year more than 40,000 organs are transplanted in the United States; from those organs, over 4500 are related to heart transplantation. Two main limitations that exist with heart transplantation are #1: the waitlist continues to increase whereas the number of donor hearts has not changed. Unfortunately, over 60% of potential donor hearts are discarded. This leads to significant waitlist mortality and an unmet and growing need. #2: if fortunate to be transplanted, the recipient is subjected to lifelong immunosuppression leading to significant burden of infections, malignancies, and end-organ dysfunction while still experiencing a high risk of acute rejection (40% of recipients within the first year) and chronic rejection (over 50% of patients by year 5). This funding opportunity leverages a unique window of therapeutic opportunity by directly targeting the donor heart PRIOR to transplant when the heart is directly accessible. Using material science, nanotechnology and drug delivery, the investigators propose to engineer a novel delivery technology that can be applied ex vivo to the donor organ after procurement and prior to transplantation to improve organ transplantation. The proposed technology consists of a polymeric sheet that contains engineered nanoparticles (NPs). The NPs have a macrophage specific targeting peptide, a fluorescent marker for tracking, and a macrophage activation inhibitor in the core, to reduce pro-inflammatory signaling and recipient neutrophil and monocyte recruitment. Although heart transplantation will be investigated in this grant, this technology may be applicable to other organs to enable a broader use of previously discarded organs and to improve post-transplant outcomes. The goal of this R21 Trailblazer award is to develop an “off-the-shelf” therapy that can exist at every organ procurement organization (OPO) and that can be easily and reliably deployed to donor organs at the time of procurement. The invention will become part of the OPOs procurement pipeline. Importantly, we aim to create a workflow that will improve outcomes and allow increased utilization of “marginal” organs. This technology could be immediately translatable and can be modified to deliver therapies in a personalized medicine approach or can be applicable to other organs.
Grant Summary
Leveraging targeted cell therapy to promote heart transplant tolerance through topical application of a nanoparticle infused polymeric membrane is a NIBIB - National Institute of Biomedical Imaging and Bioengineering grant providing up to $624K for university, nonprofit, healthcare org. Applications are due 2028-03-31 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $624K
2028-03-31
- 1Confirm your organization is eligible for Leveraging targeted cell therapy to promote heart transplant tolerance through topical application of a nanoparticle infused polymeric membrane from NIBIB - National Institute of Biomedical Imaging and Bioengineering, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIBIB - National Institute of Biomedical Imaging and Bioengineering before the deadline.
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Leveraging targeted cell therapy to promote heart transplant tolerance through topical application of a nanoparticle infused polymeric membrane: Frequently Asked Questions
Who is eligible for the Leveraging targeted cell therapy to promote heart transplant tolerance through topical application of a nanoparticle infused polymeric membrane?
Leveraging targeted cell therapy to promote heart transplant tolerance through topical application of a nanoparticle infused polymeric membrane is offered by NIBIB - National Institute of Biomedical Imaging and Bioengineering and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Leveraging targeted cell therapy to promote heart transplant tolerance through topical application of a nanoparticle infused polymeric membrane provide?
Leveraging targeted cell therapy to promote heart transplant tolerance through topical application of a nanoparticle infused polymeric membrane provides up to $624K per award from NIBIB - National Institute of Biomedical Imaging and Bioengineering. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Leveraging targeted cell therapy to promote heart transplant tolerance through topical application of a nanoparticle infused polymeric membrane deadline?
Applications for Leveraging targeted cell therapy to promote heart transplant tolerance through topical application of a nanoparticle infused polymeric membrane are due 2028-03-31 (open). Because deadlines can change, verify the date with the funder, NIBIB - National Institute of Biomedical Imaging and Bioengineering, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Leveraging targeted cell therapy to promote heart transplant tolerance through topical application of a nanoparticle infused polymeric membrane?
To apply for Leveraging targeted cell therapy to promote heart transplant tolerance through topical application of a nanoparticle infused polymeric membrane, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIBIB - National Institute of Biomedical Imaging and Bioengineering.