Implantable nitric oxide sensor
NIBIB - National Institute of Biomedical Imaging and Bioengineering
About This Grant
PROJECT SUMMARY Nitric oxide (NO) is the focus of intense research primarily because of its wide-ranging roles in human physiology and disease. The rising interest in NO research demands analytical techniques that can accurately and precisely quantify NO concentrations and production rates in vivo. The objective of this project is to design, fabricate and study the analytical performance of a needle-type NO sensor in a swine model as a function of diabetes disease state. Implantable NO sensors with robust performance characteristics will allow the ability to probe how diabetes disease state influences NO levels, which will guide future diagnostics and management of the disease. To establish this notion, we will subcutaneously implant the NO sensors for acute periods (<7 d) in swine to quantify basal NO levels in tissue as a function of disease state (i.e., healthy vs. diabetic). Additionally, we will ascertain the best practices for calibrating such devices in vivo while also establishing the use of light (e.g., wavelength, intensity, duration) to access and quantify the available NO reservoirs (e.g., S-nitrosothiols) found in tissue which liberates NO through the breakdown of S- nitrosothiols (e.g., S-nitrosoglutathione, S-nitrosocysteine, S-nitrosoalbumin). The new knowledge generated by this research may someday facilitate improved diabetes diagnostics and management by establishing the influence of basal NO levels within tissue on favorable wound healing, for example. However, implantable NO microsensor technologies may prove useful in other biomedical applications as well, including oncological, chronic inflammation, and infections.
Grant Summary
Implantable nitric oxide sensor is a NIBIB - National Institute of Biomedical Imaging and Bioengineering grant providing up to $420K for university, nonprofit, healthcare org. Applications are due 2028-03-31 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $420K
2028-03-31
- 1Confirm your organization is eligible for Implantable nitric oxide sensor from NIBIB - National Institute of Biomedical Imaging and Bioengineering, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIBIB - National Institute of Biomedical Imaging and Bioengineering before the deadline.
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Implantable nitric oxide sensor: Frequently Asked Questions
Who is eligible for the Implantable nitric oxide sensor?
Implantable nitric oxide sensor is offered by NIBIB - National Institute of Biomedical Imaging and Bioengineering and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Implantable nitric oxide sensor provide?
Implantable nitric oxide sensor provides up to $420K per award from NIBIB - National Institute of Biomedical Imaging and Bioengineering. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Implantable nitric oxide sensor deadline?
Applications for Implantable nitric oxide sensor are due 2028-03-31 (open). Because deadlines can change, verify the date with the funder, NIBIB - National Institute of Biomedical Imaging and Bioengineering, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Implantable nitric oxide sensor?
To apply for Implantable nitric oxide sensor, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIBIB - National Institute of Biomedical Imaging and Bioengineering.