Novel magnetic nanotransducers for non-invasive neural stimulation
NIBIB - National Institute of Biomedical Imaging and Bioengineering
About This Grant
Project Summary/Abstract This proposal is aimed at developing a novel magnetic nanotransducer that can provide deep tissue electric stimulation. Electrical stimulation has long been used to treat various neurological conditions such as Parkinson’s, epilepsy, pain, or sensory deficits. But it is invasive and has limitations associated the electrodes that need to be implanted. Transcranial magnetic stimulation is a non-invasive technique but suffers from poor spatial selectivity and high power consumption. Optogenetic approaches are hampered by the limited light penetration in brain tissues and usually require an implantable device. A non-invasive technique that can deliver sufficiently strong stimulation to reliably trigger neural activity, and allow targeting of specific areas or cell types, could enable designing effective, specific and long-lasting brain implants to treat a number of neurological conditions much more effectively than what’s possible today. To address this long-standing challenge, we propose to develop a novel nanotransducer that can generate electric potentials up to ~100 mV upon application of an external magnetic field. The nanotransducers have a size of a few hundred nanometers and can be directly injected into tissues or organs. Once placed in the target area, the produced voltages are controlled remotely by an external magnetic field. Thanks to the excellent tissue penetration of magnetic fields but also to the novel design of the nanotransducer, the operating distance is on the order of 1 ~ 10 centimeters, enabling truly deep tissue stimulation. Compared to the current non-invasive technologies, our approach will provide orders of magnitude stronger electrical stimulations. In this proposal, we will develop an ingenuous fabrication method to produce the nanotransducers and validate their efficacy through a comprehensive set of in-vitro, in-vivo and behavioral experiments.
Grant Summary
Novel magnetic nanotransducers for non-invasive neural stimulation is a NIBIB - National Institute of Biomedical Imaging and Bioengineering grant providing up to $595K for university, nonprofit, healthcare org. Applications are due 2029-04-30 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $595K
2029-04-30
- 1Confirm your organization is eligible for Novel magnetic nanotransducers for non-invasive neural stimulation from NIBIB - National Institute of Biomedical Imaging and Bioengineering, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIBIB - National Institute of Biomedical Imaging and Bioengineering before the deadline.
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Novel magnetic nanotransducers for non-invasive neural stimulation: Frequently Asked Questions
Who is eligible for the Novel magnetic nanotransducers for non-invasive neural stimulation?
Novel magnetic nanotransducers for non-invasive neural stimulation is offered by NIBIB - National Institute of Biomedical Imaging and Bioengineering and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Novel magnetic nanotransducers for non-invasive neural stimulation provide?
Novel magnetic nanotransducers for non-invasive neural stimulation provides up to $595K per award from NIBIB - National Institute of Biomedical Imaging and Bioengineering. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Novel magnetic nanotransducers for non-invasive neural stimulation deadline?
Applications for Novel magnetic nanotransducers for non-invasive neural stimulation are due 2029-04-30 (open). Because deadlines can change, verify the date with the funder, NIBIB - National Institute of Biomedical Imaging and Bioengineering, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Novel magnetic nanotransducers for non-invasive neural stimulation?
To apply for Novel magnetic nanotransducers for non-invasive neural stimulation, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIBIB - National Institute of Biomedical Imaging and Bioengineering.