A bioinspired strategy for informing drug combination to overcome disease-specificImmunosuppression
NIBIB - National Institute of Biomedical Imaging and Bioengineering
About This Grant
PROJECT SUMMARY Developing immunoregulatory drugs poses challenges due to the necessity for personalized treatments to address diverse immune profiles in different diseases and individuals, as well as the requirement for combination therapy to tackle the complexity of immune dysfunction. However, guidelines for designing personalized combination immunostimulatory therapeutics are lacking. To address this gap, we propose leveraging the body's natural counteracting response to disease-induced immune disorders for drug discovery in this context. Our strategy involves the intelligent utilization of the foreign body response (FBR) within a subcutaneous biomaterial scaffold implant. In health, FBR achieves homeostasis between inflammatory responses to biomaterials and anti-inflammatory biomolecules, thereby mitigating potential tissue damage. In disease, when dysfunctional immune cells infiltrate the implants and disrupt local balance, FBR will overproduce diverse biomolecules to counteract immune disorders, restoring homeostasis to some extent. Our hypothesis posits that by identifying these immunoregulatory biomolecules that assist scaffold implants in overcoming immune disorders, we can develop them into personalized combination drugs and administer them systemically to mitigate immune disorders in major organs. We will employ immunosuppression as a disease model to validate our hypothesis and seek combination drugs tailored to cancer immunosuppression and lipopolysaccharide (LPS) tolerance with varying host immunity profiles. The success of this project will offer a smart strategy to design personalized combination therapies for immune disorders across diseases.
Grant Summary
A bioinspired strategy for informing drug combination to overcome disease-specificImmunosuppression is a NIBIB - National Institute of Biomedical Imaging and Bioengineering grant providing up to $183K for university, nonprofit, healthcare org. Applications are due 2029-02-28 (open). Check eligibility and apply with FindGrants.
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How to Apply
Up to $183K
2029-02-28
- 1Confirm your organization is eligible for A bioinspired strategy for informing drug combination to overcome disease-specificImmunosuppression from NIBIB - National Institute of Biomedical Imaging and Bioengineering, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIBIB - National Institute of Biomedical Imaging and Bioengineering before the deadline.
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A bioinspired strategy for informing drug combination to overcome disease-specificImmunosuppression: Frequently Asked Questions
Who is eligible for the A bioinspired strategy for informing drug combination to overcome disease-specificImmunosuppression?
A bioinspired strategy for informing drug combination to overcome disease-specificImmunosuppression is offered by NIBIB - National Institute of Biomedical Imaging and Bioengineering and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the A bioinspired strategy for informing drug combination to overcome disease-specificImmunosuppression provide?
A bioinspired strategy for informing drug combination to overcome disease-specificImmunosuppression provides up to $183K per award from NIBIB - National Institute of Biomedical Imaging and Bioengineering. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the A bioinspired strategy for informing drug combination to overcome disease-specificImmunosuppression deadline?
Applications for A bioinspired strategy for informing drug combination to overcome disease-specificImmunosuppression are due 2029-02-28 (open). Because deadlines can change, verify the date with the funder, NIBIB - National Institute of Biomedical Imaging and Bioengineering, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the A bioinspired strategy for informing drug combination to overcome disease-specificImmunosuppression?
To apply for A bioinspired strategy for informing drug combination to overcome disease-specificImmunosuppression, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIBIB - National Institute of Biomedical Imaging and Bioengineering.