Induction and Maintenance on Buprenorphine in Opioid Use Disorder: Investigation of a peripheral nerve block for autonomic dysfunction
NIDA - National Institute on Drug Abuse
About This Grant
Project Summary: The opioid epidemic continues to evolve, with high-potency synthetic opioids (HPSO), such as fentanyl, driving recent increases in the US overdose death rate. The aim of this study is to test the impact of blocking the sphenopalatine ganglion (SPG) as an adjunctive treatment to buprenorphine maintenance. The SPG is a large autonomic ganglion that can be blocked with a local anesthetic using minimal equipment. SPG blocks have been used clinically for decades to treat refractory migraine and cluster headache. This study proposes to enroll 40 individuals with opioid use disorder (OUD) who test positive for HPSO use. All participants will receive standard treatment with transmucosal buprenorphine and will be randomized to an active versus sham SPG block. The first SPG block will be delivered just prior to induction onto buprenorphine. After that, the SPG block will be performed weekly over the course of this 8-week study. The primary outcome measures will be weekly opioid withdrawal symptoms as measured by the clinical opiate withdrawal scale and treatment acceptability as measured by adherence to the weekly SPG procedure. The primary purpose of this proposed R21 is to estimate the 95% confidence interval for the treatment effect size between active and sham SPG block, for purpose of planning future studies, which will be done using confidence interval methodology. The resulting 95% confidence interval provides considerably more information than testing a specific null hypothesis: it gives us a range of plausible effect sizes which can be used to estimate potential effect sizes in larger clinical trials.
Grant Summary
Induction and Maintenance on Buprenorphine in Opioid Use Disorder: Investigation of a peripheral nerve block for autonomic dysfunction is a NIDA - National Institute on Drug Abuse grant providing up to $450K for university, nonprofit, healthcare org. Applications are due 2028-04-30 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $450K
2028-04-30
- 1Confirm your organization is eligible for Induction and Maintenance on Buprenorphine in Opioid Use Disorder: Investigation of a peripheral nerve block for autonomic dysfunction from NIDA - National Institute on Drug Abuse, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIDA - National Institute on Drug Abuse before the deadline.
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Induction and Maintenance on Buprenorphine in Opioid Use Disorder: Investigation of a peripheral nerve block for autonomic dysfunction: Frequently Asked Questions
Who is eligible for the Induction and Maintenance on Buprenorphine in Opioid Use Disorder: Investigation of a peripheral nerve block for autonomic dysfunction?
Induction and Maintenance on Buprenorphine in Opioid Use Disorder: Investigation of a peripheral nerve block for autonomic dysfunction is offered by NIDA - National Institute on Drug Abuse and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Induction and Maintenance on Buprenorphine in Opioid Use Disorder: Investigation of a peripheral nerve block for autonomic dysfunction provide?
Induction and Maintenance on Buprenorphine in Opioid Use Disorder: Investigation of a peripheral nerve block for autonomic dysfunction provides up to $450K per award from NIDA - National Institute on Drug Abuse. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Induction and Maintenance on Buprenorphine in Opioid Use Disorder: Investigation of a peripheral nerve block for autonomic dysfunction deadline?
Applications for Induction and Maintenance on Buprenorphine in Opioid Use Disorder: Investigation of a peripheral nerve block for autonomic dysfunction are due 2028-04-30 (open). Because deadlines can change, verify the date with the funder, NIDA - National Institute on Drug Abuse, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Induction and Maintenance on Buprenorphine in Opioid Use Disorder: Investigation of a peripheral nerve block for autonomic dysfunction?
To apply for Induction and Maintenance on Buprenorphine in Opioid Use Disorder: Investigation of a peripheral nerve block for autonomic dysfunction, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIDA - National Institute on Drug Abuse.