Novel Mechanisms of Protection from Substance Abuse Drugs
NIDA - National Institute on Drug Abuse
About This Grant
SUMMARY The objective of this proposal is to determine the mechanisms that produce protective immunity for neurotropic chemicals such as fentanyl, cocaine, and nicotine. This proposal is in response to PAR-25-101 Cutting-Edge Basic Research Awards (CEBRA). Annual US overdose deaths have risen alarmingly to over 100,000 from fentanyl (FEN) which is often combined with cocaine. Additionally, annual US deaths related to nicotine addiction average 435,000. It has become evident that the development of alternative therapeutic strategies is of paramount importance. Generation of protective host immunity against addictive substances has demonstrated limited success using monoclonal antibodies or vaccines. However, we recently showed that FEN vaccination admixed with specific adjuvants and delivery routes markedly blocked FEN-induced analgesia and penetration into the brain. In addition, FEN-specific IgA correlated best with protection from FEN challenge. Additional research has recently identified meningeal plasma cells as key protective cells for the brain against infection. We believe that either IgA isotypes and/or a brain specific “antibody helmet” is the key to generating protective immunity against drugs involved in substance use disorders (SUD). Such immunity could be used to help prevent relapse and avert addiction related deaths. Here, we aim to perform basic research to define if specific antibody isotypes or locations of antibody secreting cells provide a protective phenotype from drugs involved in SUD. To achieve this, our proposal aims to conduct the following studies: (1) Test if targeted depletion of meningeal plasma cells will eliminate protective immunity against SUD in a mouse model. (2) Use two-photon cranial window imaging to determine in real time how meningeal plasma cells correlate to protection against SUD. (3) Determine if specific isotypes (e.g. IgA) or antibody locations (CSF, serum) are critical for protection against SUD. These studies have the potential to be paradigm shifting as to how best to activate host immunity to protect the brain from SUDs and toxic substances.
Grant Summary
Novel Mechanisms of Protection from Substance Abuse Drugs is a NIDA - National Institute on Drug Abuse grant providing up to $230K for university, nonprofit, healthcare org. Applications are due 2028-04-30 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $230K
2028-04-30
- 1Confirm your organization is eligible for Novel Mechanisms of Protection from Substance Abuse Drugs from NIDA - National Institute on Drug Abuse, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIDA - National Institute on Drug Abuse before the deadline.
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Novel Mechanisms of Protection from Substance Abuse Drugs: Frequently Asked Questions
Who is eligible for the Novel Mechanisms of Protection from Substance Abuse Drugs?
Novel Mechanisms of Protection from Substance Abuse Drugs is offered by NIDA - National Institute on Drug Abuse and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Novel Mechanisms of Protection from Substance Abuse Drugs provide?
Novel Mechanisms of Protection from Substance Abuse Drugs provides up to $230K per award from NIDA - National Institute on Drug Abuse. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Novel Mechanisms of Protection from Substance Abuse Drugs deadline?
Applications for Novel Mechanisms of Protection from Substance Abuse Drugs are due 2028-04-30 (open). Because deadlines can change, verify the date with the funder, NIDA - National Institute on Drug Abuse, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Novel Mechanisms of Protection from Substance Abuse Drugs?
To apply for Novel Mechanisms of Protection from Substance Abuse Drugs, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIDA - National Institute on Drug Abuse.