Contributions of RND efflux pumps to bacterial virulence
NIAID - National Institute of Allergy and Infectious Diseases
About This Grant
SUMMARY All cells need to export waste and toxic products. Gram-negative bacteria evolved multi-subunit, tripartite e:lux pumps that export molecules from the periplasm through the outer membrane. The Resistance-Nodulation-Division (RND) family of e:lux pumps are best known for expelling antibiotics, but they are also critical for infection in the absence of antibiotic treatment. Why bacteria need RND e:lux pumps during infection is not clear, and understanding their roles in virulence could facilitate the development of therapeutic inhibitors of e:lux pumps. We therefore propose to establish mechanisms by which the major Enterobacteriaceae RND e:lux pump, AcrAB-TolC, contributes to virulence. Across Enterobacteriaceae, AcrAB-TolC is needed for infection of animals. In Salmonella enterica serovar Typhimurium (STm), AcrAB-TolC is also required for proliferation in macrophages and for growth in media that mimic the macrophage phagosome microenvironment in which STm resides. We propose to establish whether AcrAB-TolC is required for infection to enable physiological responses to 1) nitrosative stress and 2) host fatty acids.
Grant Summary
Contributions of RND efflux pumps to bacterial virulence is a NIAID - National Institute of Allergy and Infectious Diseases grant providing up to $222K for university, nonprofit, healthcare org. Applications are due 2028-06-30 (open). Check eligibility and apply with FindGrants.
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Up to $222K
2028-06-30
- 1Confirm your organization is eligible for Contributions of RND efflux pumps to bacterial virulence from NIAID - National Institute of Allergy and Infectious Diseases, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
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Contributions of RND efflux pumps to bacterial virulence: Frequently Asked Questions
Who is eligible for the Contributions of RND efflux pumps to bacterial virulence?
Contributions of RND efflux pumps to bacterial virulence is offered by NIAID - National Institute of Allergy and Infectious Diseases and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Contributions of RND efflux pumps to bacterial virulence provide?
Contributions of RND efflux pumps to bacterial virulence provides up to $222K per award from NIAID - National Institute of Allergy and Infectious Diseases. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Contributions of RND efflux pumps to bacterial virulence deadline?
Applications for Contributions of RND efflux pumps to bacterial virulence are due 2028-06-30 (open). Because deadlines can change, verify the date with the funder, NIAID - National Institute of Allergy and Infectious Diseases, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Contributions of RND efflux pumps to bacterial virulence?
To apply for Contributions of RND efflux pumps to bacterial virulence, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIAID - National Institute of Allergy and Infectious Diseases.