Dissecting the Transcriptional Control of Human MAIT Cell Identity and Function by PLZF and Helios
NIAID - National Institute of Allergy and Infectious Diseases
About This Grant
Project Summary This project aims to uncover the transcriptional and metabolic mechanisms that govern the identity, function, and therapeutic potential of mucosal-associated invariant T (MAIT) cells, a non-MHC-restricted, innate-like T cell subset with growing relevance in cancer and infectious disease immunotherapy. By leveraging two clinically relevant molecular glues—CC-647 and DKY-709—that selectively degrade the transcription factors PLZF and Helios, we will precisely manipulate the transcriptional programs of MAIT cells and related innate-like lymphocytes ( T and NK cells) in primary human samples. Using integrated transcriptomic, epigenomic, metabolic, and functional profiling, this study will define how PLZF and Helios sustain MAIT cell effector poise, tissue-homing capacity, and metabolic restraint. The outcomes will enable the rational design of engineered MAIT cells with optimized persistence and functionality for off-the-shelf immunotherapies.
Grant Summary
Dissecting the Transcriptional Control of Human MAIT Cell Identity and Function by PLZF and Helios is a NIAID - National Institute of Allergy and Infectious Diseases grant providing up to $234K for university, nonprofit, healthcare org. Applications are due 2028-03-31 (open). Check eligibility and apply with FindGrants.
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Focus Areas
Eligibility
How to Apply
Up to $234K
2028-03-31
- 1Confirm your organization is eligible for Dissecting the Transcriptional Control of Human MAIT Cell Identity and Function by PLZF and Helios from NIAID - National Institute of Allergy and Infectious Diseases, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIAID - National Institute of Allergy and Infectious Diseases before the deadline.
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Dissecting the Transcriptional Control of Human MAIT Cell Identity and Function by PLZF and Helios: Frequently Asked Questions
Who is eligible for the Dissecting the Transcriptional Control of Human MAIT Cell Identity and Function by PLZF and Helios?
Dissecting the Transcriptional Control of Human MAIT Cell Identity and Function by PLZF and Helios is offered by NIAID - National Institute of Allergy and Infectious Diseases and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Dissecting the Transcriptional Control of Human MAIT Cell Identity and Function by PLZF and Helios provide?
Dissecting the Transcriptional Control of Human MAIT Cell Identity and Function by PLZF and Helios provides up to $234K per award from NIAID - National Institute of Allergy and Infectious Diseases. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Dissecting the Transcriptional Control of Human MAIT Cell Identity and Function by PLZF and Helios deadline?
Applications for Dissecting the Transcriptional Control of Human MAIT Cell Identity and Function by PLZF and Helios are due 2028-03-31 (open). Because deadlines can change, verify the date with the funder, NIAID - National Institute of Allergy and Infectious Diseases, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Dissecting the Transcriptional Control of Human MAIT Cell Identity and Function by PLZF and Helios?
To apply for Dissecting the Transcriptional Control of Human MAIT Cell Identity and Function by PLZF and Helios, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIAID - National Institute of Allergy and Infectious Diseases.