Mapping the determinants of bedaquiline resistance in Mycobacterium tuberculosis
NIAID - National Institute of Allergy and Infectious Diseases
About This Grant
SUMMARY Bedaquiline (BDQ) is recently developed antibiotic that is used to treat extensively drug-resistant Mycobacterium tuberculosis (Mtb). The vast majority of BDQ resistance mutations are in the non-essential mmpR gene (Rv0678). Resistance to many anti-Mtb drugs can be inferred directly from gene sequences; however, this is not the case for BDQ resistance, largely because there are insufficient data linking specific mmpR mutations with resistance. In this proposal, we will use saturating mutagenesis to create a comprehensive database of mmpR loss-of-function mutations that lead to BDQ resistance. This database can be used together with whole-genome or amplicon sequencing approaches to rapidly diagnose resistance in clinical isolates. In parallel, we will test the ability of this database to predict BDQ resistance in clinical isolates of Mtb. Our long-term goal is to incorporate BDQ resistance profiling into existing genetic analysis pipelines.
Grant Summary
Mapping the determinants of bedaquiline resistance in Mycobacterium tuberculosis is a NIAID - National Institute of Allergy and Infectious Diseases grant providing up to $404K for university, nonprofit, healthcare org. Applications are due 2028-03-31 (open). Check eligibility and apply with FindGrants.
Focus Areas
Eligibility
How to Apply
Up to $404K
2028-03-31
- 1Confirm your organization is eligible for Mapping the determinants of bedaquiline resistance in Mycobacterium tuberculosis from NIAID - National Institute of Allergy and Infectious Diseases, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIAID - National Institute of Allergy and Infectious Diseases before the deadline.
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Mapping the determinants of bedaquiline resistance in Mycobacterium tuberculosis: Frequently Asked Questions
Who is eligible for the Mapping the determinants of bedaquiline resistance in Mycobacterium tuberculosis?
Mapping the determinants of bedaquiline resistance in Mycobacterium tuberculosis is offered by NIAID - National Institute of Allergy and Infectious Diseases and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Mapping the determinants of bedaquiline resistance in Mycobacterium tuberculosis provide?
Mapping the determinants of bedaquiline resistance in Mycobacterium tuberculosis provides up to $404K per award from NIAID - National Institute of Allergy and Infectious Diseases. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Mapping the determinants of bedaquiline resistance in Mycobacterium tuberculosis deadline?
Applications for Mapping the determinants of bedaquiline resistance in Mycobacterium tuberculosis are due 2028-03-31 (open). Because deadlines can change, verify the date with the funder, NIAID - National Institute of Allergy and Infectious Diseases, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Mapping the determinants of bedaquiline resistance in Mycobacterium tuberculosis?
To apply for Mapping the determinants of bedaquiline resistance in Mycobacterium tuberculosis, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIAID - National Institute of Allergy and Infectious Diseases.