Discovery of antimicrobial metabolites from the human gut microbiota using high-throughput screening
NIAID - National Institute of Allergy and Infectious Diseases
About This Grant
Project Summary The human gut microbiota plays a critical role in health, with one of its major roles being to protect the host from microbial pathogens through a phenomenon known as colonization resistance. Effective colonization resistance is associated with increased bacterial diversity within the gut microbiota, which likely enhances the functional capabilities of the community. One microbial function thought to be important for colonization resistance is the production of antimicrobial small molecules by gut bacteria. However, our current understanding of the specific gut microbial metabolites involved in colonization resistance is limited, with identified compounds being largely restricted to previously known microbial products, including short-chain fatty acids, bile acid derivatives, and antimicrobial peptides. We hypothesize that the gut microbiota produces additional metabolites with antimicrobial activity that that are important for colonization resistance. The overall objective of this application is to discover such compounds through high-throughput screening. Specifically, we will screen a library of gut bacterial culture and supernatant extracts for growth inhibitory activity against a panel of bacterial and fungal pathogens and pathobionts relevant to the human gut microbiota (Aim 1). We will then isolate and structurally characterize antimicrobial metabolites from gut bacterial supernatants or cell pellets with promising activity (Aim 2). The proposed studies are supported by a preliminary screen demonstrating the presence of antibacterial and antifungal activity from multiple extracts in the library. To our knowledge, high-throughput screening has not been used previously to identify antimicrobial metabolites from members of the human microbiota. The proposed research therefore has high potential to identify antimicrobial compounds from these organisms, setting the stage for future efforts to understand the biological activities and roles of these metabolites within the gut microbiota, including their contributions to colonization resistance. Ultimately, our findings will provide a foundation for developing novel antimicrobial therapies and enhancing the resilience of the gut microbita against infections.
Grant Summary
Discovery of antimicrobial metabolites from the human gut microbiota using high-throughput screening is a NIAID - National Institute of Allergy and Infectious Diseases grant providing up to $463K for university, nonprofit, healthcare org. Applications are due 2028-01-31 (open). Check eligibility and apply with FindGrants.
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Focus Areas
Eligibility
How to Apply
Up to $463K
2028-01-31
- 1Confirm your organization is eligible for Discovery of antimicrobial metabolites from the human gut microbiota using high-throughput screening from NIAID - National Institute of Allergy and Infectious Diseases, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
- 4Review every section against the requirements checklist, then export a submission-ready application pack and submit it to NIAID - National Institute of Allergy and Infectious Diseases before the deadline.
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Discovery of antimicrobial metabolites from the human gut microbiota using high-throughput screening: Frequently Asked Questions
Who is eligible for the Discovery of antimicrobial metabolites from the human gut microbiota using high-throughput screening?
Discovery of antimicrobial metabolites from the human gut microbiota using high-throughput screening is offered by NIAID - National Institute of Allergy and Infectious Diseases and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Discovery of antimicrobial metabolites from the human gut microbiota using high-throughput screening provide?
Discovery of antimicrobial metabolites from the human gut microbiota using high-throughput screening provides up to $463K per award from NIAID - National Institute of Allergy and Infectious Diseases. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Discovery of antimicrobial metabolites from the human gut microbiota using high-throughput screening deadline?
Applications for Discovery of antimicrobial metabolites from the human gut microbiota using high-throughput screening are due 2028-01-31 (open). Because deadlines can change, verify the date with the funder, NIAID - National Institute of Allergy and Infectious Diseases, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Discovery of antimicrobial metabolites from the human gut microbiota using high-throughput screening?
To apply for Discovery of antimicrobial metabolites from the human gut microbiota using high-throughput screening, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIAID - National Institute of Allergy and Infectious Diseases.