Defining the mechanism of CNS inflammation induced by colitis
NIAID - National Institute of Allergy and Infectious Diseases
About This Grant
Inflammatory Bowel Diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are life-long diseases characterized by cycles of active flares and remission. Disease flares result in significant inflammation in the colon, as well as pathology in other organ systems, including the brain. Central nervous system (CNS) dysfunction is a well-established comorbidity in patients with IBD. We have recently demonstrated CNS inflammation, and specifically inflammasome activation, is induced in the CNS of mice in an acute colitis model using a novel mouse model in which inflammasome activation induces tissue bioluminescence. In this grant, we seek to understand the mechanisms by which CNS inflammation is induced in this and similar models. We seek to extend exciting preliminary data which reveal that colitis results in the presence of a factor or factors in serum that drive CNS inflammation to identify this factor and the mechanism by which is induces inflammasome activation in the CNS. We also propose to use a newer version of our mouse model, in which expression of our luciferase based caspase-1 biosensor is restricted to specific cell lineages in the CNS, allowing us to understand the impact of colitis and CNS inflammation on specific cell populations.
Grant Summary
Defining the mechanism of CNS inflammation induced by colitis is a NIAID - National Institute of Allergy and Infectious Diseases grant providing up to $424K for university, nonprofit, healthcare org. Applications are due 2028-01-31 (open). Check eligibility and apply with FindGrants.
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Up to $424K
2028-01-31
- 1Confirm your organization is eligible for Defining the mechanism of CNS inflammation induced by colitis from NIAID - National Institute of Allergy and Infectious Diseases, checking organization type, location, and any population or project requirements.
- 2Gather the required documents and information, including your organization details, project plan, and budget figures.
- 3Draft your application narrative and budget addressing the funder's priorities and review criteria. FindGrants can draft each section for you to review and edit.
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Defining the mechanism of CNS inflammation induced by colitis: Frequently Asked Questions
Who is eligible for the Defining the mechanism of CNS inflammation induced by colitis?
Defining the mechanism of CNS inflammation induced by colitis is offered by NIAID - National Institute of Allergy and Infectious Diseases and is generally open to university, nonprofit, healthcare org. It is open to organizations nationwide unless the funder specifies otherwise. Review the specific eligibility terms before applying, since funders set their own requirements around organization type, location, and the population or project being served.
How much funding does the Defining the mechanism of CNS inflammation induced by colitis provide?
Defining the mechanism of CNS inflammation induced by colitis provides up to $424K per award from NIAID - National Institute of Allergy and Infectious Diseases. Actual award sizes depend on the scope of your project, available program funds, and the number of applicants, so build a budget that reflects realistic, allowable costs rather than the maximum figure.
When is the Defining the mechanism of CNS inflammation induced by colitis deadline?
Applications for Defining the mechanism of CNS inflammation induced by colitis are due 2028-01-31 (open). Because deadlines can change, verify the date with the funder, NIAID - National Institute of Allergy and Infectious Diseases, and give yourself enough time to prepare a complete, competitive application before the close date.
How do you apply for the Defining the mechanism of CNS inflammation induced by colitis?
To apply for Defining the mechanism of CNS inflammation induced by colitis, confirm your eligibility, gather the required documents, and prepare a narrative and budget that address the funder's priorities. FindGrants guides you step by step and can draft each section, then exports a submission-ready application pack for this grant from NIAID - National Institute of Allergy and Infectious Diseases.